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Techniques for Assessing the Health Risks of Dermal Contact with Chemicals in the Environment
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
Dennis J. Paustenbach, Hon-Wing Leung
Ethylenediamine (EDA) was the most potent skin sensitizer of the amines tested. Diethylenetriamine (DETA) was next in potency. Triethylenetetramine (TETA), aminoethylethanolamine (AEEA), and aminoethylpiperazine had moderate potency. Tetraethylenepentamine (TEPA), piperazine (PIP), pentaethylenehexamine (PEHA), and hydroxyethylpiperazine (HEP) had low potencies.
Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Andrea Angeli, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso, Claudiu T. Supuran
(ii) VchCAβ was more sensitive to activation with the amines and amino acids investigated here, which showed KAs in the range of 0.18–20.3 µM (Table 2). The most effective activators were D-Tyr 10, dopamine 13, serotonin 14, 2-pyridyl-methylamine 15, 2-aminoethylpyridine 16, and 2-aminoethylpiperazine 17, which showed activation constants in the submicromolar – low micromolar range, of 0.18–1.37 µM. Apart D-Tyr, all of these most effective activators are amines. Another subset of derivatives, such as 4–9, 11, 12, 18, and 19 were slightly less effective CAAs with KAs in the range of 4.18–12.8 µM. They include both amino acid and amine derivatives. The least effective activators were L/D-His and L-Phe, with KAs in the range of 15.4–20.3 µM. Again, generally D-enantiomers of the amino acids were generally more effective activators compared to the L-enantiomers (for His, Phe, DOPA, and Tyr), whereas in the case of Trp, the L-enantiomer was a better activator compared to the D one (Table 1).