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Analgesics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Medical compounds comprised of isometheptene, dichloralphenazone and acetaminophen (Midrin, Amidrin, Migratine) are used to treat vascular headaches or migraines. The combination of isometheptene, a sympathomimetic drug that causes vasoconstriction and dichloralphenazone, a mild sedative, is commonly used during pregnancy. However, no studies of the risk of congenital anomalies are published for either of the two components (isometheptene, dichloralphenazone).
Specific Disease Conditions
Published in Harold G. Koenig, Chronic Pain, 2013
Drugs used in acute therapy must work quickly to stop the headache before it reaches its full severity. These drugs can be taken as a pill or as a nasal spray, or can be injected under the skin (subcutane-ously). Medications that can be taken orally in tablet form at the start of an attack include, from weakest to strongest: acetaminophen and aspirin (Excedrin Migraine), nonsteroidal anti-inflammatory drugs (Naprosyn), ergotamine-type medications (cafergot or Wigraine), drug combinations (Midrin, which is a combination of acetaminophen, a mild sedative, and blood vessel constrictor), sumatriptan (Imitrex) or zolmitriptan (Zomig), barbiturate combinations (Fioricet or Fiorinal), and narcotics (Percodan or Percocet).
Reductions in acute medication use and healthcare resource utilization in patients with chronic migraine: a secondary analysis of a phase 3, randomized, double-blind, placebo-controlled study of galcanezumab with open-label extension (REGAIN)
Published in Journal of Medical Economics, 2022
Joshua A. Tobin, Shivang Joshi, Janet H. Ford, Russell M. Nichols, Shonda A. Foster, Dustin Ruff, Holland C. Detke, Sheena K. Aurora
Acute medication use for headache was captured in the daily eDiary. The number of migraine headache days per month with acute headache medication use was a prespecified secondary outcome measure based on patients’ eDiary entries. Allowable headache treatments included acetaminophen (paracetamol); nonsteroidal anti-inflammatory drugs (NSAIDs); triptans; ergotamine and derivatives; isometheptene mucate, dichloralphenazone, and acetaminophen combination (Midrin); or combinations thereof. The following medications were allowed with restrictions: (1) opioid and barbiturates no more than 3 days/month and (2) single dose of injectable steroids allowed only once during the study, in an emergency setting. The name and dose of concomitant medications used for the acute treatment of migraine or headache and the use of other pain medications were captured.
Safety and efficacy of galcanezumab in Taiwanese patients: a post-hoc analysis of phase 3 studies in episodic and chronic migraine
Published in Current Medical Research and Opinion, 2020
Chun-Pai Yang, Chia-Fang Lee, Grazia Dell’Agnello, Hans-Peter Hundemer, Sarah Lipsius, Shuu-Jiun Wang
According to the protocols for both EVOLVE-2 and REGAIN the concomitant use of acute medications to treat migraine was allowed, inclusive of the following: acetaminophen (paracetamol), NSAIDs; triptans; ergotamine and derivatives; isometheptene mucate, dichloralphenazone and acetaminophen combination (Midrin); or combinations thereof. Use of opioid- and barbiturate-containing medications was restricted to no more than 3 days per month, and a single dose of injectable steroids was allowed only once during the study, in an emergency setting.