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Common Medicines from Herbs, Minerals and Animal Sources
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Aloe consists of therapeutically active constituents related to a range of biological effects, including antiviral, anti-inflammatory, laxative, fungicidal, antibacterial, immunomodulating and antimicrobial activities (Cosmetic Ingredient Review Expert Panel, 2007). It has been used for hundreds of years to empirically manage a wide range of diseases like diabetes, ulcers, skin ailments, including (burns and psoriasis), hyperlipidemia, SLE and constipation. Aloe vera synthesis has been a rising industry for manufacturing functional food, laxative medicines and cosmetics like cleansers, lotions, toners, makeup, wipes, shampoos, foundations, creams, shaving creams and hand creams (Guo & Mei, 2016).
Role of Aloe vera in Irritable Bowel Disease
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Dilipkumar Pal, Souvik Mukherjee
It is validated that Aloe vera plays significant role in intestinal inflammatory conditions that has led to the development of different natural formulations. It is important to note that most botanical drugs are going through tight testing so as to recognize these pharmaceutical agents, in an attempt to maintain standard of herbal drugs.31,36,38
Constipation
Published in Charles Theisler, Adjuvant Medical Care, 2023
Stimulants: Stimulants including rhubarb, aloe, castor oil, bisacodyl (Ducodyl, Dulcolax, Correctol), and senna (Senokot, Fletcher’s Castoria, Ex-Lax regular strength pills) cause the intestines to contract.2 There is strong evidence that aloe juice (100–200 mg/day), which contains latex is a powerful laxative.4 Bisacodyl taken by mouth should produce a bowel movement within 6–12 hours. Senna is an FDA-approved over-the-counter (OTC) laxative. The herbal liquid laxative senna (5–15 mL once or twice a day) is commonly used to relieve constipation.5 Senna can be used with psyllium or the stool softener docusate (Colace, Dulco Ease) in adults, including the elderly, and is considered safe and effective in children.6 It is also effective for treating constipation in people who have undergone anorectal surgery.7
Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia
Published in Drug Delivery, 2022
Khaled M. Hosny, Waleed Y. Rizg, Eman Alfayez, Samar S. Elgebaly, Abdulmohsin J. Alamoudi, Raed I. Felimban, Hossam H. Tayeb, Rayan Y. Mushtaq, Awaji Y. Safhi, Majed Alharbi, Alshaimaa M. Almehmady
In this wok, we aimed to Enhancee the solubility and permeation of Finasteride through the formulation of the drug in the form of nanocubosomes using Design of Experiments (DoE) to develop the best optimized formulation of the delivery vehicle. In this study, oregano oil was used as an oil component in the formulation of nanocubosomes while also taking advantage of its benefits in promoting hair growth, treating some scalp problems such as Alopecia Areata, and having antimicrobial activity that will stop the Propionibacterium acnes, which is the main bacterial infection that affects the scalp in cases of Alopecia Areata. Furthermore, Aloe ferox gel was used as a carrier for the loaded nanocubosomes to ensure intimate contact between the loaded nanocubosomes and the scalpel due to its adhesiveness and viscosity. Aloe ferox also has several benefits in skin treatment as an antimicrobial, anti-inflammatory, and hair growth promoter.
Topical and oral applications of Aloe vera improve healing of deep second-degree burns in rats via modulation of growth factors
Published in Biomarkers, 2022
Ayman Atiba, Walied Abdo, Ehab Ali, Marwa Abd-Elsalam, Mohamed Amer, Ahmed Abdel Monsef, Reda Taha, Samar Antar, Ayman Mahmoud
Aloe vera (A. vera) is a drought-resistant, stemless succulent plant from the Lily family. It is native to hot climates and has been utilised medicinally by different cultures, including the Egyptian, Indian, Chinese, and European cultures for about five thousand years (Pol et al. 2016). A. vera gel is a mucilaginous gummy aqueous extract that has been shown to exert anti-inflammatory, antioxidant, immunoboosting, anti-cancer, healing-promoting, anti-aging, and anti-diabetic efficacies (Ray and Ghosh 2014). Aloe species have been used as a traditional medicine for a long time. It has been rolled out for the treatment of a variety of inflammatory digestive and skin ailments, including inflammatory bowel disease (Radha and Laxmipriya 2015, Sherafatmanesh and Ekramzadeh 2018). For many centuries, A. vera has been used as a hold house remedy for burns, and several recent studies have investigated its efficacy in greater depth (Qadir 2009, Hekmatpou et al. 2019). Aloe gel is a rich source of polysaccharides of which mannose-6-phosphate and acemannan are the major constituents responsible for its immunomodulatory and antitumor activities (Gao et al. 2019). Recently, It is re-emerging as a viable treatment to counteract infection in open wounds, and chronic ulcers (Hekmatpou et al. 2019). The purpose of our study was to evaluate the effect of oral and topical administration of A. vera on cutaneous wound healing induced by deep second-degree burn, focussing on wound closure, and antioxidant and growth factors in normal rats.
The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage
Published in Toxicology Mechanisms and Methods, 2022
A. Wallace Hayes, Roger A. Clemens, Peter Pressman
Some studies have suggested that Aloe vera exposure causes toxicity while other studies have reported no untoward effects. For example, the hydroxyanthracene glycosides in Aloe vera have been reported to be genotoxic to bacteria and mammalian cells (Boudreau et al. 2013). A 2013 report, however, indicated that decolorized Aloe vera juice did not increase mutagenesis using the Salmonella typhimurium TAl00 strain (Sehgal et al. 2013a). A DNA damage repair assay demonstrated the absence of a dose-related increase in SOS transgene induction. In addition, the juice did not induce DNA damage repair in the presence of S9 extract; however, at high concentrations, the juice appeared to be either cytotoxic or bacteriostatic in the Escherichia coli system. The investigators concluded that the effect on bacterial growth was not indicative of increased DNA damage.