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History and Sources of Essential Oil Research
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
During 1884–1914, Wallach wrote about 180 articles that are summarized in his book Terpene und Campher (Wallach, 1914) compiling all the knowledge on terpenes at that time, and already in 1887, he suggested that the terpenes must be constructed from isoprene units. In 1910, he was honored with the Nobel Prize for Chemistry “in recognition of his outstanding research in organic chemistry and especially in the field of alicyclic compounds” (Laylin, 1993).
Response to the letter to the editor from Carrillo and Danneels
Published in Critical Reviews in Toxicology, 2020
Ralph Pirow, Nicole Hellwig, Bettina Huhse, Christoph Hutzler, Andreas Luch
The second issue raised by Drs. Carrillo and Danneels is the human relevance of granuloma formation observed in F-344 rats. While acknowledging that we clearly recognize the differences among animal species and strains in their response to different mineral oils and waxes, the commentators claim that we do not fully discuss the consequences of this interspecies issue. Compared to other animal species and strains, the F-344 rat is a data-rich animal model. It appears that it is also the most sensitive one when it comes to displaying adverse effects in response to mineral oil and wax exposure. A large amount of data is available for F-344 rats from studies with oral administration of various substances, comprising highly refined mineral oils and waxes as well as an n-alkane-poor, broad MOSH mixture being relevant to human dietary exposures. For the latter, there are indications that the F-344 rat data can be plausibly extrapolated to humans to mimic the liver accumulation of the compounds present in “MOSH” mixtures that mainly consist of highly branched and alicyclic compounds (see page 758). The situation is, however, completely different for n-alkane-rich substances such as the Low Melting Point hydrocarbon Waxes (LMPW).