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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
The fruit and leaves of the tree contain a complicated mix of phytochemicals, including flavonoids, iridoid glycosides, alkaloids, essential oils, fatty oils, diterpenoids, and steroids.4 Among those phytochemicals – some that are shared with other medicinal species and others that are unique to Vitex agnus-castus – are: vitexin, casticin, agnuside, aucubin, apigenin, thujene, pinene, sabinene, myrcene, terpinene, limonene, cineole, linalool, cryptone, citronellol, cumin aldehyde, carvacrol, b-caryophyllene, farnesene, myristicin, and scores of others.5
Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants
Published in James A. Duke, Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants, 2017
“Chaste Tree”AGNUSIDE LF HHBAUCUBIN LF HHBCASTICINE SD HHBCINEOLE FR HHBEO 4,700 FR HHBHOMOOREINTTN LF HHBLUTEOLIN-7-GLUCOSIDE LF HHBPINENE FR HHB
Aldose reductase inhibitors: 2013-present
Published in Expert Opinion on Therapeutic Patents, 2019
Luca Quattrini, Concettina La Motta
Julius Angeline from India tested different polyhydroxylated derivatives against ALR2, identifying a small number of compounds showing inhibitory efficacy in the nanomolar range [85]. These include the cyclopenta[c]pyran-5-oles agnuside 43 (IC50 22.4 nM) and picroside II 44 (IC50 130 nM), and the croman-3-ones derivatives eupalitin-3-O-galactoside 45 (IC50 27.3 nM) and 7-O-methylwogonin 46 (IC50 108 nM) (Figure 7). By combining agnuside and eupatilin-3-O-galactoside the author succeeded in obtaining an active phytocomplex which proved to inhibit ALR2 from both ARPE19 human retinal pigment epithelial cell line and diabetic lens, showing IC50 values lower than the commercially available ALR2 inhibitor epalrestat.
Long-term effects of a combination of isoflavones, agnus castus and magnolia extracts on climacteric symptoms and cardiometabolic risk profile in postmenopausal women
Published in Gynecological Endocrinology, 2022
Silvia Maffei, Michela Franchini, Loredana Fortunato, Letizia Guiducci
In this interventional and prospective study, subjects received one tablet per day (taken before going to bed) containing a combination of soy isoflavones 60 mg (genistein 30 mg and daidzein 30 mg); Lactobacillus sporogenes one billion spores; Magnolia officinalis bark extract (50 mg) equivalent to honokiol 0.75 mg, Vitex agnus-castus L. fruit extract (40 mg) equivalent to agnuside 0.2 mg, vitamin D3 (5 μg), calcium (141 mg) (Estromineral Serena Plus®, Viatris Pharma; hereafter referred to as combined isoflavone compound [CIC]).