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Role of Medicinal Plants in the Treatment of Hemorrhoids
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Yaw Duah Boakye, Daniel Obeng Mensah, Eugene Kusi Agyei, Richard Agyen, Christian Agyare
Extracts of Aesculus hippocastanum L. contain flavonoids and aescin as its main active biocomponents, with antioxidant activity, venotonic properties, anti-inflammatory activity, and vascular protective effects.25,32 The seed extract of A. hippocastanum could decrease capillary permeability, edema, and antagonize enzymes involved in the degradation of proteoglycan.47 In a clinical study, the gel from the 20% glycerolic extract of A. hippocastanum seeds induced a statistically significant reduction of hind paw edema. In other clinical trials, it was observed that acute symptomatic hemorrhoids were improved after 6 days of administration to patients.48
Chemistry and Pharmacology of Naturally Occurring Flavoalkaloids
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Rashmi Gaur, Jyoti Gaur, Nikhilesh Kumar
(-)-licorice glycoside E was the first indole flavoalkaloid identified (51), in 1997, from the roots of Glycyrrhiza uralensis Fisch, commonly known as Tohoku licorice (Figure 21.2) (Hatano et al., 1998). The absolute configuration of 51 was determined with the help of CD spectra. Hubner et al. (1999) isolated the oxindole-flavoalkaloid (52) from the seeds of the horse chestnut Aesculus hippocastanum L. (Figure 21.2). The presence of sugar moieties was confirmed by acid-hydrolysis, semi-synthesis of its derivatives and gas chromatography. Kapusta et al. (2007) isolated from the same plant, and an ion consistent with the deoxy analog 53 was analyzed using mass spectrometry (Figure 21.2) (Kapusta et al., 2007).
Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
The extracts of the seeds of Aesculus hippocastanum are used mainly in Europe to treat hemorrhoidal disease (both internally and externally). Several clinical trials have been conducted on this subject over the years which highlighted that the clinical symptoms were successfully managed after 1 week of administration to the patients under trial along with improved physical state of hemorrhoids. The therapeutically active constituent present in the seed extracts is aescin, a combination of triterpene saponins which exists in two forms α and β, of which, β-aescin is the most active one. Aescin also demonstrates anti-inflammatory, venotonic, and antiedematous activities which have indirect applications in treating the symptoms of hemorrhoids (Fig. 11.1).
Contributions of Avicenna to surgery and anesthesiology
Published in Acta Chirurgica Belgica, 2020
Moreover, he suggested a particular medication to allow quicker wound healing: it consisted of three ingredients: (1) Kale Pache (sheeps’s head and feet); (2) Harisah (Haleem), which is gradually cooked with a glue like substance, prepared from wheat flour, rice, beef’s fat and milk (Haleem is an Arabic word for ‘patience’, because it takes quite a lot of time and endurance to prepare it); (3) Kaak: dry toasted bread that can be squashed and powdered; (4) Aesculus hippocastanum L. nuts [33].
Targeting Major Signaling Pathways of Bladder Cancer with Phytochemicals: A Review
Published in Nutrition and Cancer, 2021
Connor Chestnut, Dharmalingam Subramaniam, Prasad Dandawate, Subhash Padhye, John Taylor, Scott Weir, Shrikant Anant
Escin is a mixture of triterpenoid saponins that occurs in Aesculus hippocastanum, or the horse chestnut tree (224). Cheng et al. showed escin to inhibit tumor growth in xenograft mouse models, and to induce bladder cancer cells apoptosis through ROS generation and cytochrome C release (225). This study also found escin inhibits STAT3 protein expression and reduce nuclear levels of NF-κB (225).
Himalayan poisonous plants for traditional healings and protection from viral attack: a comprehensive review
Published in Toxin Reviews, 2022
Shriya Pathania, Diksha Pathania, Priyanka Chauhan, Mamta Sharma
Saponin is referred to as triterpene glycosides and is a toxic plant-derived organic chemical. They form soap-like froth when shaken in water. Saponins are also used as an adjunct in the formation of various vaccines. These are found in oleandrin (Nerium oleander), esculin (Aesculus hippocastanum), ginsenosides Rb1, Rb2, Re, and Rg1(Ginseng sp.), etc.