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Advanced Formulation Techniques Including Innovative Materials
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Bozena Michniak-Kohn, Tannaz Ramezanli, Frank Romanski, Cliff Milow, Kishore Shah
Belfer (2009) has previously reported that when a dermal matrix–stimulating peptide is combined with a myoinhibitory botanical extract such as Spilanthes acmella oleracea, the mixture upon application to skin enhances the speed of dermal matrix rejuvenation. Repeated treatment to facial skin of such a composition results in faster reduction of fine lines and wrinkles. The hypothesis leading to the Belfer discovery originates from universal knowledge about the wound healing process within collagenous elements of mammalian tissues, and in particular, external skin. During cutaneous wound healing the collagen fibres within the injured dermis reorganize and repair best when they are not subjected to disruptive movement or under contractile tension. Furthermore, mechanical stimulation of dermal cells causes them to secrete more elastase and collagenase, and this reduces the skin’s ability to generate collagen fiber precursors. The objective of combining the myoinhibitory vegetal extract with the peptide is to provide the most favorable environment within which compositions for rejuvenating the dermis can have maximum effect. In order for the healing of expression lines to take place in the fastest manner, the contractibility of muscle fibres must be suppressed quickly, and intensely, over a sustained period of time. Once this condition is met, repair of the dermal matrix can occur with efficient delivery of matrix-stimulating peptides. Spilanthes acmella oleracea helps to create such an environment. This discovery has been utilized in some commercially marketed antiaging, wrinkle-reduction cosmetic products.
Chemical composition and broad-spectrum anthelmintic activity of a cultivar of toothache plant, Acmella oleracea, from Mizoram, India
Published in Pharmaceutical Biology, 2020
Pawi Bawitlung Lalthanpuii, Kholhring Lalchhandama
Among well-established medicinal plants, Acmella oleracea (L.) R.K. Jansen (Asteraceae) is interesting because of its multifaceted applications in traditional medicines and cuisines (Abeysiri et al. 2013). The common name, toothache plant, is given owing to its practical usage in dental health care. It is commonly consumed either cooked or raw as a vegetable or used as food seasoning because of its unique menthol-like minty flavour (Paulraj et al. 2013). It is used in the treatment of anaemia, cancer, constipation, diuresis, fever, flatulence, inflammation, liver abscess, peptic ulcer, and ulcer (Dubey et al. 2013). It is also used in severe malaria cases and has been shown to be effective on malarial parasites (Spelman et al. 2011). In addition, it is known in Indian medicine as an aphrodisiac and is used as a therapy for impotency. It is also used for treating articular rheumatism, dysentery, snakebite, and tuberculosis (Prachayasittikul et al. 2013). The plant extract has been successfully tested for anti-inflammatory (Kim et al. 2018), analgesic, antipyretic (Chakraborty et al. 2010), antimicrobial, antioxidant (Savadi et al. 2010), and insecticidal activities (Simas et al. 2013).