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Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, Sarwar Beg
Acacia is growing throughout India, particularly in the wild. The extract of this plant acts as an anti-diabetic agent by acting as a secretagogue to secrete insulin. In the experiment, it induces hypoglycemia in control rats. In powdery seeds of Acacia administered to normal rabbits at a weight of 2, 3, and 4 g/kg, the hypoglycemic effect is caused by insulin-releasing in the pancreas cells (Wadood et al., 1989).
Role of Natural Agents in the Management of Diabetes
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Monika Elżbieta Jach, Anna Serefko
Acacia gum is a water-soluble DF indigestible to both humans and animals. Although the DF intake is low in the human diet, the impact of fiber on the prevention of T2DM and its complications has been documented well (Danesh et al., 2007). Gum Arabic has nutritional value and some impact on the metabolism of glucose and lipids (Babiker et al., 2017).
Ethnobotanical Survey for Managing Selected Non-Communicable Diseases
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Godwin Ojochogu Adejo, Sunday Ene-Ojo Atawodi, Kingsley Okoyomoh
Acacia nilotica leaves are used in Senegal as antiscorbutic while the bark and gum were reportedly used for the treatment of cancers and tumors.140 The plant has high levels of tannin, which contributes to its medicinal use as a powerful astringent, molluscicide, and algicide.140Acacia nilotica can be used to treat ailments, such as: cough, leprosy, and dysentery.68
Topical delivery of growth factors and metal/metal oxide nanoparticles to infected wounds by polymeric nanoparticles: an overview
Published in Expert Review of Anti-infective Therapy, 2020
FGF-10, FGF-7, and FGF-2 are three important GFs in FGF family (22 members) with wound-healing properties (Figure 6(b)). FGF-2, basic FGF, is produced by fibroblasts, keratinocytes, mast cells, endothelial cells, chondrocytes, and smooth muscle cells. FGF-2 is decreased and increased in chronic and acute wounds, respectively. Chitosan and its derivatives can be utilized to deliver many healing factors due to its biocompatibility, antimicrobial activities, and biodegradability [49]. Wang and coworkers used chitosan as a cross-linker polymer for the production of collagen sponge. In this work, wound dressing with recombinant human acidic FGFs showed the highest dermal cell proliferation and TGF-β1 expression in a rat model with diabetic wounds after 14 days of treatment [50]. Ionic gelation method was applied to prepare CMC NPs by the diameter of 32.68 ± 6.83 nm. FGF-2 was incorporated in these NPs with a final diameter of 34.83 ± 5.89 nm. The increased release rate of FGF-2 after 48 hours in pH 5.8 (58.47%) compared to pH 7.4 (36.46%) was an important result of this study which is caused by protonation of – NH2 groups of NPs [51]. There are two major sources of this biopolymer including Acacia senegal and Acacia seyal tree. Anti-inflammatory, antimicrobial, and wound-healing properties have been linked to the natural polymer of gum Arabic [52]. Pectin is a natural polysaccharide with emulsification, stabilization, and biocompatibility abilities [53]. FGF-2 was loaded into the bioinspired hydrogels synthesized from gum arabic and pectin. The wound closures after 3 days of treatment by this hydrogel were 60% compared to control with 17% value. Moreover, the bioinspired hydrogels showed complete reepithelialization after 14 days of treatment [54].
Designing orodispersible films containing everolimus for enhanced compliance and bioavailability
Published in Expert Opinion on Drug Delivery, 2020
Yidi Ma, Rou Guan, Shuying Gao, Wei Song, Yubo Liu, Yang Yang, Hongzhuo Liu
It was reported that EVR is extremely likely to be oxidatively degraded through a radical mechanism [1], therefore, antioxidants or stabilizers need to be added in the resulting formulations. The stability of various EVR sublingual ODFs was evaluated at a temperature of 60°C for 10 days, where the stability indicator measured for that period was the remaining content of EVR. As shown in Figure 1(a), a high content of film-forming agent HPMC alone could not effectively protect EVR from oxidation. EVR films loading BHT, L-malic acid, and sodium sulfite displayed an apparent degradation of EVR, with the evidence of more than 80% reduction in drug content. On the contrary, the films loading acacia gum exhibited a slight change in EVR content, thus, acacia gum was selected as the stabilizer for subsequent study. Interestingly, in cases with the same quantities of acacia gum, the formulation with a higher HPMC E5 content (7.2%, w/v) protected EVR more effectively compared to that of the low content group (6%, w/v), as shown in Figure 1(a). Nevertheless, the films containing 7.2% HPMC E5 had higher Young’s modulus values, with a lower percent elongation (Table 3). Thus, 6% w/v HPMC E5 was used in subsequent investigations and the impact of acacia gum level on the stability of EVR was shown in Figure 1(b). As expected, more EVR was maintained in the films with an increasing concentration of acacia gum. Acacia gum is composed of polysaccharides and glycoproteins, and has slight emulsifying properties [25]. It also works as an effective stabilizer since it provides a protective matrix around dispersed compounds by trapping them inside the matrix, preventing contact with air and subsequent oxidation [26]. More importantly, acacia gum was approved by the FDA and is generally regarded to be safer compared to BHT, which had the potential to cause carcinogenicity and hyperactivity disorder in some children.