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Human Gut Microbiota–Transplanted Gn Pig Models for HRV Infection
Published in Lijuan Yuan, Vaccine Efficacy Evaluation, 2022
At PCD7, mean relative abundance was significantly higher for Bacteroides, Collinsella, and unclassified members of Clostridiaceae and Erysipelothichaceae in HHGM pigs compared to that in UHGM pigs. UHGM pigs had a significantly higher mean relative abundance of Ruminococcus, Streptococcus, Clostridium, Bifidobacterium, Staphylococcus, Turicibacter, Propriobacterium, Haemophilus, Moraxella, Blautia, Prevotella, Granulicatella, and unclassified members of Enterobacteriaceae, Bacillales, Lachnospiraceae, and Clostridiales than the HHGM pigs (Twitchell et al., 2016).
Bacteriophage Involvement in Neurodegenerative Diseases
Published in David Perlmutter, The Microbiome and the Brain, 2019
However, further analysis revealed that only some of these bacteria were correlated with Alzheimer’s severity. The increased abundance of Bacteroides and Blautia, along with a greater amyloid burden in the brain, were positively correlated with disease severity. Conversely, a negative correlation was revealed for bacteria that were less abundant in Alzheimer’s, such as Turicibacter, SMB53, and Dialister, and a more difficult Alzheimer’s pathology. One thing that particularly attracted our attention was the decrease of the Bifidobacterium genus, whose actions are associated with an altered immune response, chronic inflammation, and impaired intestinal permeability.61
Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients
Published in Gut Microbes, 2022
Hana Čipčić Paljetak, Anja Barešić, Marina Panek, Mihaela Perić, Mario Matijašić, Ivana Lojkić, Ana Barišić, Darija Vranešić Bender, Dina Ljubas Kelečić, Marko Brinar, Mirjana Kalauz, Marija Miličević, Dora Grgić, Nikša Turk, Irena Karas, Silvija Čuković-Čavka, Željko Krznarić, Donatella Verbanac
When comparing fecal abundances between all four groups, the most prominent shifts were found in Firmicutes phylum. Christenellaceae, Ruminococacceae, Anaerostipes and Adlercreutzia were depleted in CD and UC, all taxa associated with microbiome of healthy individuals.28,40–42 Compared to healthy individuals increased abundance of Lactobacillaceae was found in patient groups, consistent with prior studies.30,43,44 Significant increase of Turicibacter found in UC patients, to our knowledge, has not been reported so far. Depletion of Turicibacter was, however, found in a limited cohort of new-onset non-Western pediatric CD patients.45 While observed reduction of Phascolarctobacterium in IBD is in keeping with studies linking its decrease to colonic inflammation,46 overabundance of Eubacterium contrasts the reported reduction in pediatric and adult IBD patients.27,47,48
Effect of gastric fluid aspiration on the lung microbiota of laboratory rats
Published in Experimental Lung Research, 2018
Sade M. B. Finn, Uwe Scheuermann, Zoie E. Holzknecht, William Parker, Joshua A. Granek, Shu S. Lin, Erin A. McKenney, Andrew S. Barbas
The source of the Romboutsia and Turicibacter predominating in the aspirated lung remains unknown. It seems plausible that the organisms were either acquired from the environment or were present in the healthy lung in vanishingly small quantities. An alternative but not mutually exclusive explanation is that the organisms reside in the healthy host in a compartment outside the lung (e.g., in the gastrointestinal tract), and that the growth in the lung was facilitated by the aspiration and the subsequent response to that aspiration. Indeed, species from the genera Turicibacter are one of the dominant species in the rat cecum.18 Further, both Romboutsia and Turicibacter are strictly anaerobic and have been isolated in the gut microbiota of several animals, including humans.53–55 Furthermore, migration of bacteria from the gastrointestinal tract to the injured lung has been suggested by Dickson et al using a mouse model. In that model,44 lung samples that were either septic or undergoing acute respiratory distress syndrome were enriched with gut-associated bacteria. Thus, it seems likely that, in laboratory rodent models, the injured lung might be colonized by enteric organisms. Whether this might happen in humans, however, is questionable, given the dramatic differences between the normal hygiene practices of modern humans versus those of laboratory rodents. Nevertheless, studies addressing this issue are warranted.
Effects of a synbiotic on the fecal microbiome and metabolomic profiles of healthy research cats administered clindamycin: a randomized, controlled trial
Published in Gut Microbes, 2019
Jacqueline C. Whittemore, Jennifer E. Stokes, Joshua M. Price, Jan S. Suchodolski
Quantitative PCR was performed for total bacterial DNA, Faecalibacterium spp., Turicibacter spp., Streptococcus spp., Escherichia coli, Blautia spp., Fusobacterium spp., and Clostridium hiranonis as previously described.1,41 For this, 5 μl of a DNA-binding dye,h 0.4 μl each of a forward and reverse primer (final concentration: 400 nM), and 2.6 μl of PCR water were combined with 2 μl of normalized DNA (final concentration: 5 ng/μl) for a total reaction volume of 10 μl. Data were expressed as log amount of DNA (fg) for each particular bacterial group per 10 ng of isolated total DNA. Oligonucleotide primers and probes, as well as respective annealing temperatures, were as previously described.1