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Alginate and Hydrogel Applications for Wound Dressing
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Dina Fransiska, Ellya Sinurat, Fera Roswita Dewi, Hari Eko Irianto
Various types of biopolymers have been used to make wound dressing products based on alginate. Their functional groups interact with other biopolymers easily and form a cross-linked network structure. An ideal wound dressing should have the desirable features of therapeutic options, such as offering a moist microenvironment, germ access protection, wound exudate absorption, tissue regeneration stimulation, and support to natural wound recovery processes. Alginate-based hydrogels are effective for the application of wound dressing (Liao et al., 2018). This is because alginates as bioactive compounds can improve hydrogel properties with intrinsic swelling capabilities, particularly biodegradation, optimum moisture transport via vapors, and exudate absorption. Hydrogel features a waterproof and extensively interlinked hydrophilic network of polymers (Ahmed, 2015). They were blended with natural and synthetic components. Based on hydrogels’ synthetic and natural components, a three-dimensional swelling capacity network has been exhibited in various mediums (Figure 13.5) (Varaprasad et al., 2020).
Dry-Fill Formulation and Filling Technology
Published in Larry L. Augsburger, Stephen W. Hoag, Pharmaceutical Dosage Forms, 2017
Pavan Heda, Vikas Agarwal, Shailesh K. Singh
Diluents should be chosen based on the solubility of the API to aid release. Solubility of the active and the excipients is the major contributory factor in disintegration and dissolution. The more water soluble the formulation, the quicker it disintegrates and releases the drug substance. In the case of substances that are poorly soluble in water, the disintegration and release depend heavily on disintegrants and diluents. Insoluble drugs should ideally be mixed with soluble diluents (e.g., lactose) in order to make the mixture more hydrophilic. Soluble drugs can be mixed with insoluble diluents (e.g., starch) in order to avoid competition for solution. Primary factors influencing drug release rate from a capsule are particle size and aqueous solubility of the drug. Interactions between various components within a formulation can either accelerate or inhibit the release of drug from the capsule, for example, competition for available water between a highly soluble drug and a disintegrant with a high swelling capacity may exist, which can result in retarded dissolution.
Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d -panthenyl triacetate as combinational treatment
Published in Pharmaceutical Development and Technology, 2021
Ali Asram Sağıroğlu, Burak Çelik, Eray Metin Güler, Abdurrahim Koçyiğit, Özgen Özer
The prepared liposomal film formulation did not show adhesive characteristics when used on a dehydrated membrane however enhance bio-adhesive when used on a moist membrane. Thanks to the water molecules, dry film formulation is converted to the gelling polymer layer. This outcome has shown that SA, which are hydrophilic polymers, become bioadhesive properties thanks to their ability to ensure hydrogen bonds. In addition, the electrostatic charge of the polymer is an important factor affecting the bioadhesion strength. The carboxyl groups of SA are negatively charged with influential hydrogen bonding groups that form hydrogen bonds with negatively charged biological tissue and indicate much greater bioadhesion to biological tissue than neutral polymers (Padula et al. 2007). Also, the bioadhesion value is directly concerned with the swelling capacity of formulation. Increasing the swelling index capacity of the polymer allows the formulation to have more bioadhesive properties (Momin et al. 2016).
Stimuli-responsive/smart tablet formulations (under simulated physiological conditions) for oral drug delivery system based on glucuronoxylan polysaccharide
Published in Drug Development and Industrial Pharmacy, 2020
Gulzar Muhammad, Muhammad Tahir Haseeb, Muhammad Ajaz Hussain, Muhammad Umer Ashraf, Muhammad Farid-ul-Haq, Muhammad Zaman
Various tablet formulations (Table 1) were evaluated for their swelling behavior in buffer solutions of pH 1.2, 6.8, 7.4, and deionized water (DW) at 37 °C (mimicked body temperature) for 10 h [25,26]. Buffer solutions were prepared according to the standard procedure reported in USP 32. Tablets were enclosed in tea bags and placed in DW and buffer solutions of different pH. After fixed time intervals, tea bags were removed from the media and calculated the weight of the swollen tablets. Then, tea bags were again placed in their respective media for further swelling. The swelling study was carried out until no further swelling of the tablets was observed. The swelling capacity or swelling index (g/g) was determined using Equation (1). Wt is the weight of wet tea bag with swollen tablet, Ww is the weight of wet tea bag (empty) and Wi is the weight of the dry tablet.
Production of Hypericum perforatum oil-loaded membranes for wound dressing material and in vitro tests
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Control of moisture at the wound area is very important [1]. Extreme moisture or the dryness of the wound delays healing [1]. Capacity of exudate absorption (wettability) of the wound dressing is important in terms of maintaining moisture control of the wound. Degree of swelling ratios (%) of the membranes with/without oil (Membrane 0 & 1) sketched in Figure 3. Membranes exhibited fast and linear swelling ratios (%) within the first three minutes. At third minute, swelling ratios of the membrane 0 (around 90%) was higher than membrane 1 (around 170%). Swelling was balanced at 12th minute for membrane 1 (around 120%) and at 25th minute for membrane 0 (around 290%). Comparing the swelling ratios of the membranes at balance, swelling capacity decreased by half in the case of oil loading. It can be concluded that decreasing porosity together with hydrophilicity by oil loading resulted with a decrease in the capacity to absorb moisture. Wettability of the membrane 0 was greater than wettability of the membrane 1; however, both membranes have satisfactory capacities to absorb moisture [28,30].