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Nail changes in systemic diseases and drug reactions
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
Rheumatoid nodules occur in one-fifth of patients with rheumatoid arthritis although mainly over extensor surfaces at the elbows, metacarpophalangeal and interphalangeal joints. Rarely, they are seen on the distal pads, the free margin of the nails, and the dorsal aspect of the fingers. They may even occur without typical rheumatoid arthritis, particularly in accelerated rheumatoid nodulosis.134,135
Unattended compared to traditional blood pressure measurement in patients with rheumatoid arthritis: a randomised cross-over study
Published in Annals of Medicine, 2021
Elena Bartoloni, Fabio Angeli, Elisa Marcucci, Carlo Perricone, Giacomo Cafaro, Clara Riccini, Lorenzo Spighi, Benedetta Gildoni, Claudio Cavallini, Paolo Verdecchia, Roberto Gerli
From February 2019 to June 2020, consecutive Caucasian RA outpatients attending the Rheumatology Unit and meeting the American College of Rheumatology (ACR) or the 2010 ACR/European League Against Rheumatism classification criteria were included in the study [15,16]. Patients not able to understand or to provide written informed consent and patients with conditions precluding a correct electrocardiography (ECG) assessment of left ventricular hypertrophy (complete right bundle branch block, left bundle branch block, atrial fibrillation, pathological Q waves due to prior myocardial infarction and Wolf-Parkinson-White syndrome) or a correct blood pressure measurement as severe obesity (body mass index ≥40) were excluded. All patients underwent a detailed medical interview and clinical examination. For the purpose of the study, the following parameters were specifically collected: anthropometric measures, smoking status (current, former, never), diabetes mellitus, history of HT and previous CV events, which included acute coronary syndrome (ST-elevation and non-ST elevation myocardial infarction and unstable angina pectoris), chronic ischaemic heart disease, cerebrovascular events (stroke or transient ischaemic attack), peripheral arterial occlusive disease with or without revascularization procedures and heart failure with reduced ejection fraction. Diabetes mellitus was defined by a fasting glucose of ≥7.0 mmol/L (126 mg/dL) or use of antidiabetic drugs. Biochemical data were retrieved from patient medical records and included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) as mean of the last three values, lipid status (cholesterol, triglycerides, high density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol), glycaemia, glomerular filtration rate and uric acid concentration. Disease-specific parameters included presence of erosions, extra-articular involvement (namely pulmonary, ocular, cutaneous, rheumatoid nodulosis and cardiac except for CV events as defined), rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) positivity.