China
Africa
Explore chapters and articles related to this topic
Marine Fungi-Derived Secondary Metabolites: Potential as Future Drugs for Health Care
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
Syed Shams Ul Hassan, Hui-Zi Jin, Abdur Rauf, Saud Bawazeer, Hafiz Ansar Rasul Suleria
The cyclic tetrapeptide penicopeptide A (image 16 in Figure 8.1) was isolated from the culture broth of the endophytic fungus (Penicillium commune) that was derived from the leaves of mangrove plant (Vitis vinifera) in Gansu province of China. The compound penicopeptide A was examined against 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme; and it exhibited potent inhibitory activity against human 11β-HSD1, with an IC50 value of 9.07 ± 0.61μM. From these studies, it has been revealed that the novel structure of the compound penicopeptide A with its potent inhibitory activities against 11β-HSD1 opens the gates for more 11β-HSD1 inhibitors from marine natural products [54].
Patulin
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
Alejandro Hernández, Alicia Rodríguez, Santiago Ruiz-Moyano, Francisco Pérez-Nevado, Juan J. Córdoba, Alberto Martín
The ability for patulin production has been demonstrated in different food-related mold species, including Aspergillus flavus, Aspergillus oryzae, Aspergillus tamarii, Aspergillus toxicarius, Penicillium aurantiogriseum, Penicillium camemberti, Penicillium commune, Penicillium expansum, Penicillium polonicum, Penicillium verrucosum, Emericella quadrilineata, Emericella rugulosa, and Emericella variecolor [47]. In spite of the wide diversity of mold producers, there are limited foodstuffs where the patulin presence has been reported as relevant. Rodríguez-Carrrasco et al. [48] demonstrated that milled grain-based products including wheat, rice, maize, spelt, oat, soy, and tapioca, did not harbor patulin contamination. Other foods have shown their potential to be an exposure source of patulin through intake. Grape must and retail wines from the Mosel-Saar-Ruwer wine-growing area (Germany) presented mean values of 15.6 μg/L of patulin in 54% of the positive samples [49]. Dried figs can be a source of exposure, because high levels (39.3–151.6 μg/kg) have been detected in Turkish cull figs [50]. Pattono et al. [51] found concerning levels of patulin (>50 μg/kg) in the rind of 6–32 handmade semihard Italian cheeses. Furthermore, different foodstuffs as meat products or spices harbor patulin-producing strains [52–53].
Therapeutic potentials of endophytes for healthcare sustainability
Published in Egyptian Journal of Basic and Applied Sciences, 2021
Ayodeji O. Falade, Kayode E. Adewole, Temitope C. Ekundayo
The antidiabetic activity of a number of endophytic extracts and compounds have been reported by various studies [63–65]. The search on the antidiabetic activity of endophytes using ‘antidiabetic’ as the key word in equation 1 returned 33 items, 39% of which, were published between 2018 and 2020. ‘Glucosidase inhibition’ and ‘amylase inhibition’ together returned 8 items, of which, 50% were published between 2018 and 2020. From some of these studies, the endophytic Aspergillus awamori isolated from Acacia nilotica was reported with the ability to produce an uncharacterized peptide with alpha glucosidase and alpha amylase inhibitory activities [66]. The extract and the compounds: ‘(S)-(+)-2-cis-4-trans-abscisic acid, 7ʹ-hydroxy-abscisic acid and 4-des-hydroxyl altersolanol A’ obtained from Nigrospora oryzae hosted by Combretum dolichopetalum were reported to exhibit ability to reduce the fasting blood sugar of alloxan-induced diabetic mice [67]. Also, peniisocoumarins C, G and I, obtained from Penicillium commune QQF-3, have exhibited strong inhibitory activity against alpha-glucosidase [68].