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The gastrointestinal system
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Sharon J. White, Francis A. Carey
Odontogenic tumours are uncommon lesions derived from various tissue components involved in tooth development. Most are benign although malignant types do very rarely occur. The most frequently seen benign odontogenic tumours are odontomas and ameloblastoma. Odontomas are the most common odontogenic tumours and typically arise in childhood, when they often impede the eruption of a permanent tooth, and early adulthood. These tumours are hamartomatous lesions containing enamel and dentine and sometimes cementum. A complex odontoma consists of a disorganized mass of dental tissues, whereas a compound odontoma consists of numerous small tooth-like structures. Ameloblastoma is the second most common odontogenic tumour. It is derived from odontogenic epithelium and has a distinct histological appearance (Figure 10.5). Ameloblastoma most frequently arises in the molar region of the mandible. It is locally aggressive, often producing extensive bone destruction. The majority of ameloblastomas have been found to possess mutations in MAPK pathway genes.
The Classification of Odontogenic Cysts
Published in Roger M. Browne, Investigative Pathology of the Odontogenic Cysts, 2019
The inclusion of laterally placed cysts in this classification indicates that the development of a cystic lesion in this position may arise by a variety of different pathogenetic mechanisms. In addition to the laterally placed radicular cyst, odontogenic keratocysts, lateral periodontal cysts and inflammatory collateral cysts may all give a similar radiographical appearance. Further, a variety of odontogenic tumors may also arise in this position.
Cysts and Tumours of the Bony Facial Skeleton
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Julia A. Woolgar, Gillian L. Hall
Odontogenic tumours, a spectrum of lesions unique to the jaws, are derived from tooth-forming apparatus.50 They range from hamartoma-like dental malformations (odontomas) through to benign neoplasms, locally invasive growths, malignant neoplasms with metastatic potential to primary intraosseous carcinomas with few, if any, odontogenic features. An abbreviated form of the WHO classification,50 based on behaviour and pathogenesis, is shown in Table 25.5. Odontomas account for around one-third. Of the true neoplasms, excluding the keratocystic odontogenic tumour, recently redesignated as an odontogenic tumour, the ameloblastoma is as common as all other types combined. Diagnosis depends on clinical and radiological features as well as the precise histology, hence, accurate information on location, relationship to teeth, circumscription and radiodensity should be submitted to the reporting pathologist.51 Odontogenic tumours tend to reflect morphological features and inductive interactions of normal tooth germs and histological distinction between some tumours relies on subtle features. The rarity of many lesions, and hybrid forms, add to the diagnostic challenge.
Odontogenic myxoma involving the right nasal cavity, orbital floor, and skull base in a 20-year-old woman: Removal and review of the literature
Published in Acta Oto-Laryngologica Case Reports, 2023
Danlin Huang, Fei Liu, Junyi Liang, Xiao Xing, Xingsha Wu, Shuai Yang, Xinfeng Wei, Shuo Li
According to previous studies, the overall incidence of OM was an ethnic disparity. The West China College of Stomatology at Sichuan University conducted a retrospective analysis of 1642 cases of odontogenic tumors between 1952 and 2004 and discovered that only 4.6 per cent of odontogenic tumors in the Chinese population were caused by OM [6]. Argentinean teenagers and Egyptian daiquiri had a higher incidence of OM, making up 8.5% of individuals with odontogenic tumors [7,8] and in a California survey of the United States performed that accounted for 2.2% [9]. In this study, we reported a 20 years old female with OM, which occurs in the maxillary posterior interdental region and maxillary sinus, as well as involves the right nasal cavity, orbital floor, and skull base.
Pindborg tumor in early childhood: a rare tumor in the youngest patient reported to date
Published in Case Reports in Plastic Surgery and Hand Surgery, 2022
Brian W. Starr, Elizabeth A. Lax, Angelo A. Leto Barone, Raquel M. Ulma, Brian S. Pan, Haithem M. Elhadi Babiker
Clinical exam revealed mild left-sided facial swelling without signs of infection. Intraorally, bony expansion of the left posterior mandible was noted. There was no tooth mobility and her oral mucosa was intact. Her clinical findings were suggestive of an odontogenic tumor. Given the patient’s age, clinical findings of asymptomatic expansion, posterior mandibular location, and the CT findings, a benign odontogenic pathology was suspected. Given the patient’s age and the low risk of malignancy in the presentation, we decided to proceed directly to definitive treatment. Tumor enucleation and peripheral ostectomy was planned.
Ameloblastoma: a retrospective single institute study of 34 subjects
Published in Acta Odontologica Scandinavica, 2019
Jetta Kelppe, Jaana Hagström, Timo Sorsa, Anna Liisa Suominen, Satu Apajalahti, Caj Haglund, Hanna Thorén
Geographic and racial varieties exist in age of onset, sex ratios, location, histology and clinical findings [5,6]. For example, North American patients with ameloblastoma have been shown to be afflicted with ameloblastoma significantly later in life than patients in Asia [5]. In China and Africa, ameloblastoma is the commonest odontogenic tumour, while in North America, odontomas are considered more common [7–10]. Ameloblastoma cohorts collected in hospital districts tend to remain small. Every study on this rare tumour contributes toward resolving demographic differences.