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Linezolid
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Mycoplasma pneumoniae and Ureaplasma urealyticum are resistant to linezolid (MIC90 > 64 mg/l for both), whereas testing using agar dilution suggests that linezolid has modest activity against Mycoplasma hominis (MIC90 8 mg/l, range 2–8 mg/l) (Kenny and Cartwright, 2001). More recently, Mycoplasma genitalium and Ureaplasma parvum have also been shown to be resistant to linezolid, whereas Mycoplasma fermentans is relatively susceptible with an MIC90 of 4 mg/l (range 0.5–4 mg/l) (Waites et al., 2009).
Epidemiology, Transmission, and Medical Management
Published in Judith Landau-Stanton, Colleen D. Clements, Robert E. Cole, Ann Z. Griepp, Alexander F. Tartaglia, Jackie Nudd, Elisabet Espaillat-Piña, M. Duncan Stanton, AIDS, Health, and Mental Health, 1993
Judith Landau-Stanton, Colleen D. Clements
Some researchers maintain that the full story of this virus may be complicated by co-factors. Both Dr. Montagnier and Dr. Lo have found co-infection with mycoplasma fermentans, which enhances the capacity of HIV to kill cells. The theory is that this mycoplasma may be heavily involved in the development of AIDS.10 Also, although the CD4 molecule is the principal cell receptor for HIV in the immune system, neural cell lines may have a receptor called galactosyl ceramide, which some researchers feel could be the route for entry into the central nervous system.11
Metataxonomic and metaproteomic profiling of the oral microbiome in oral lichen planus - a pilot study
Published in Journal of Oral Microbiology, 2023
Maria Bankvall, Miguel Carda-Diéguez, Alex Mira, Anders Karlsson, Bengt Hasséus, Roger Karlsson, Jairo Robledo-Sierra
To identify putative protein biomarkers in OLP lesions, we used mass spectrometry to detect the bacterial proteins expressed in our samples and compare their presence between affected and non-affected oral mucosa of patients with OLP. Consequently, peptides were annotated using a protein database based on the Human Oral Microbial Database (Supplementary Table S1), confirming the presence of bacteria identified by 16S rRNA sequencing. Most peptides corresponded to basic metabolic functions such as the 30S and 50S ribosomal subunits, DNA/RNA metabolism, or ABC transporters. Other peptides were annotated as hypothetical proteins, and their annotation could not be refined. Several peptides were putatively annotated as belonging to G. haemolysans, previously detected by our 16S rRNA analysis as a potential OLP biomarker. Also, many peptidases were found in the proteome data, potentially having a virulence function (Supplementary Table S2). Interestingly, some bacteria associated with the OLP group were identified in the metaproteome that were not amplified by the 16S rRNA gene sequencing approach, including the pathogen Mycoplasma fermentans.