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Hypoxia, Free Radicals, and Reperfusion Injury Following Cold Storage and Reperfusion of Livers for Transplantation
Published in John J. Lemasters, Constance Oliver, Cell Biology of Trauma, 2020
Ronald G. Thurman, Wenshi Gao, Henry D. Connor, Sigrid Bachmann, Robert T. Currin, Ronald P. Mason, John J. Lemasters
Changes in liver function and histology due to storage injury commonly occur postoperatively. After liver transplantation, a dramatic elevation of serum transaminases typically occurs one to three days postoperatively, sometimes followed by a syndrome of functional cholestasis characterized by sustained high bilirubin, low bile flow, and centrilobular hepatocellular ballooning and feathery degeneration.109 These disturbances typically resolve within three weeks, but in some transplant patients, ischemic biliary strictures may develop.110 The incidence of these strictures increases with the length of storage time, but their etiology remains unknown. In addition, storage injury may predispose patients to immunological rejection, with portal inflammation, endothelialitis, and disappearance of bile ducts.111
Phenotype-Genotype Correlation of North Indian Progressive Familial Intrahepatic Cholestasis type2 Children Shows p.Val444Ala and p.Asn591Ser Variants and Retained BSEP Expression
Published in Fetal and Pediatric Pathology, 2020
Suvradeep Mitra, Ashim Das, Baburam Thapa, Rakesh Kumar Vasishta
Intracanalicular and intrahepatocytic cholestasis was present in eight (80%) and nine cases (90%), respectively. Feathery degeneration and pseudoacinar transformation was noted in eight (80%) and seven cases (70%) respectively. Giant cell transformation was present in five cases (50%). One case showed <33% involvement of the core area by the giant cells and one case showed involvement of nearly 80% of the core area (>67%) by the giant cells [Fig. 1d]. Three cases showed 34–66% core area involvement by the giant cells. Lobular inflammation was present in five cases (50%) and was mild in four patients and moderate in one patient. Lobular focus of extramedullary hematopoiesis was absent. However, one case (Case 7) showed portal collection of myeloid and erythroid precursor cells (10%). None of the cases showed steatosis. No dysplastic foci were noted (Table 5].
Oleanolic Acid Suppressed DMBA-Induced Liver Carcinogenesis through Induction of Mitochondrial-Mediated Apoptosis and Autophagy
Published in Nutrition and Cancer, 2021
Samar Hosny, Heba Sahyon, Magdy Youssef, Amr Negm
Although there are many beneficial effects of OA, the high doses and long-term use can produce adverse effects. OA administration produced dose-dependent pathological lesions to the liver, including inflammation, hepatocellular apoptosis, necrosis, and feathery degeneration indicative of cholestasis that appears to be due to disruption of bile acid hemostasis, resulting in bile acid-induced liver injury. Thus, caution should be taken when using OA and OA-type triterpenoids for long term to treat liver and other disorders (32–34).