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Doripenem
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Doripenem has In vitro activity demonstrated against a number of Gram-positive bacilli, although the studies have been with limited collections of isolates. Doripenem appears to have equivalent activity to meropenem against a variety of Nocardia spp. (Lai et al., 2011). The MIC to Listeria monocytogenes is low (n = 48; MIC90 0.25 μg/ml), although no break point is defined (Jones et al., 2009). Among Bacillus spp., the MIC varies (range: < 0.06 to > 8 μg/ml) (Jones et al., 2009). The MIC appears to vary between different Corynebacterium spp. Corynebacterium amycolatum (MIC90 2 μg/ml; 14 isolates) is more susceptible than C. jeikeium (MIC90 > 8 μg/ml) and C. striatum (MIC90 > 4 μg/ml) (Goldstein et al., 2008; Jones et al., 2009).
Presumed Microbial Keratitis Cases Resulting in Evisceration and Enucleation in Sydney, Australia
Published in Ocular Immunology and Inflammation, 2023
Maria Cabrera-Aguas, Pauline Khoo, Stephanie L. Watson
Thirty-three corneal scrapes were performed in 30 patients. Three were repeat scrapings. Culture positivity rate of corneal scrapes was 72% (n = 24/33). Twenty-eight organisms were identified, 26 (93%) bacteria and 2 (7%) fungi. Half of the bacteria were Gram-positive organisms (Table 3). Polymicrobial infection was detected in four corneal scrapings. Fusarium spp. and Corynebacterium amycolatum were noted in one sample. A combination of two bacteria was found in three samples (Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA); Staphylococcus warneri and Staphylococcus epidermidis; and Staphylococcus epidermidis and Staphylococcus hominis). The predominant Gram-positive and Gram-negative organisms were the coagulase-negative staphylococci (CoNS) group (6 of 28, 21%) with Staphylococcus epidermidis as the predominant species (n = 3) and Pseudomonas aeruginosa (9 of 27, 32%), respectively (Table 3).
New Insights of Corynebacterium kroppenstedtii in Granulomatous Lobular Mastitis based on Nanopore Sequencing
Published in Journal of Investigative Surgery, 2022
Xin-Qian Li, Jing-Ping Yuan, Ai-Si Fu, Hong-Li Wu, Ran Liu, Tian-gang Liu, Sheng-Rong Sun, Chuang Chen
In nanopore sequencing method, 39 (78.0%) were positive, which was significantly higher than culture methods (p < 0.001) (Figure 1A). Fourteen genera were detected from 39 patients, and 18 species from 38 patients (Figure 1D). Consistently, the dominant genera and species were Corynebacterium (32/50, 64%) and C. kroppenstedtii (28/50, 56%), respectively. Notably, C. kroppenstedtii coexisted with other pathogens in five cases, including one with fungi (Table S1); other Corynebacterium species were also detected, such as Corynebacterium tuberculostearicum, Corynebacterium urealyticum, and Corynebacterium amycolatum.
Microbiological profile and antibiotic susceptibility trends in orbital cellulitis in India: an analysis over 15 years
Published in Orbit, 2022
Joveeta Joseph, Roshni Karolia, Savitri Sharma, Harithaa Choudhary, Milind N. Naik
Four patients required surgical intervention, and therefore had an additional orbital pus sample available for comparison between conjunctival swab isolate and orbital isolate. Of these four, two cases yielded the same organisms (S. aureus and S. epidermidis, respectively). The third case yielded S. aureus in swab while the orbital biopsy showed no growth (possibly due to prior medical treatment). The fourth case yielded S. epidermidis in the conjunctival swab while orbital biopsy revealed Corynebacterium amycolatum and Aspergillus flavus.