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Enterovirus 68 and Human Respiratory Infections
Published in Sunit K. Singh, Human Respiratory Viral Infections, 2014
Janette C. Rahamat-Langendoen, Hubert G.M. Niesters
Picornaviridae with the same physical characteristics as enteroviruses have been found in many animals; however, these animal Picornaviridae are not able to infect humans.3 One of the most well-known animal Picornaviridae is foot-and-mouth disease virus, member of the genus Aphthovirus, with a high economic impact.
Nonpolio Enteroviruses, Polioviruses, and Human CNS Infections
Published in Sunit K. Singh, Daniel Růžek, Neuroviral Infections, 2013
Human enteroviruses (HEVs) are members of the Enterovirus genus in the Picornaviridae family. This family consists of the following genera: Aphthovirus, Cardiovirus, Enterovirus, Hepatovirus, Parechovirus, Erbovirus, Kobuvirus, and Teschovirus (Carsten and Ball 2009).
Foot and mouth disease vaccine strain selection: current approaches and future perspectives
Published in Expert Review of Vaccines, 2018
The causative agent of FMD is foot and mouth disease virus (FMDV), a member of the genus Aphthovirus in the family Picornaviridae. It is a nonenveloped single stranded positive sense RNA virus containing a genome, ~ 8.3 kb in length enclosed in a viral capsid [5]. The genome contains a single open reading frame (ORF) that codes for four structural (VP1–4) and 8–10 non-structural proteins. The viral capsid comprises 60 copies of each of the 4 structural proteins. One copy of each of the structural protein form a protomer, 5 protomers form a pentamer, and 12 pentamers form the complete capsid. VP1, 2 and 3 are on the surface of the virus and are comprised essentially of 8 antiparallel β sheets linked to each other by loop structures to form a β barrel, whereas VP4 is internal and has little secondary structure [5].
Challenges in foot-and-mouth disease virus strain selection as an input to attain broad vaccine intraserotype cross-protection
Published in Expert Review of Vaccines, 2021
Ingrid E. Bergmann, Viviana Malirat, Andrea Pedemonte, Eduardo Maradei
The causative agent, FMD virus (FMDV), belongs to the genus Aphthovirus within the Picornaviridae family [2]. It consists of a single-stranded positive-sense RNA genome of approximately 8500 bases surrounded by a nonenveloped icosahedral capsid constituted by 60 copies of each of the four structural proteins (VP4, VP2, VP3, and VP1). VP4 is internal.