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Developmental and Acquired Disorders of The Spine
Published in Milosh Perovitch, Radiological Evaluation of the Spinal Cord, 2019
This is a part of a generalized disorder of the spine known as spondylosis deformans or spinal osteophytosis. The detailed study conducted by Schmorl and co-workers represents the basis of our present pathologic concept of this disorder.37 Cervical spondylosis may affect the spinal cord directly by compression creating cervical spondylotic myelopathy that has been recognized as a distinct clinical entity since the work done by Clarke and Robinson. They separated this condition from the cervical myelopathy which originates from an acute disk herniation.38, 39 Most of the patients with a cervical spondylosis (demonstrated on radiographs) will not develop clinical evidence of myelopathy.
The History of Ankylosing Spondylitis
Published in Barend J. van Royen, Ben A. C. Dijkmans, Ankylosing Spondylitis Diagnosis and Management, 2006
The commonly observed osseous alterations of spondylosis deformans and AS have been described in both humans and animals, dating back to prehistoric times. Rogers et al. (1) reviewed the available literature and concluded that many paleopathological specimens, previously reported as AS, are examples of diffuse idiopathic skeletal hyperostosis (DISH) or other seronegative spondylarthropathies. So the antiquity and paleopathology of AS need reappraisal.
Genetic diseases mimicking multiple sclerosis
Published in Postgraduate Medicine, 2021
Chueh Lin Hsu, Piotr Iwanowski, Chueh Hsuan Hsu, Wojciech Kozubski
Numerous lacunar infarctions in the basal ganglia and white matter hyperintensities are seen under brain MRI [71]. The lesions are mostly located in the periventricular and deep white matter. Subcortical U-fibers involvement is less common. Subsequently, the extension of lesions into the thalamus, brainstem, and cerebellum have been documented [71,72]. Characteristic advanced disease stage MRI findings include infratentorial and external capsule lesions. Atrophies are found in different locations in the brain as the disease progresses. In the early stage, atrophy is located mainly in the central cortex and brainstem; frontal and temporal cortex atrophy is remarkable in the middle stage; cerebellar atrophy predominates in the advanced stage [72]. Spinal disk herniations and spondylosis deformans around lower thoracic and /or upper lumbar regions under MRI are shown in CARASIL patients present with low back pain [70]. OCB analysis is mostly negative [65,66,68,69].
Efficacy and safety/tolerability of pridinol: a meta-analysis of double-blind, randomized, placebo-controlled trials in adult patients with muscle pain
Published in Current Medical Research and Opinion, 2022
Michael A. Überall, Ute Essner, Gerhard H. H. Müller-Schwefe
Response to PRI (and placebo) differed among the pain syndromes evaluated (see Figure 6). Highest global response rates were seen for PRI /placebo in patients suffering from spondylosis deformans (82.6/59.1%), followed by those with cervicobrachial syndrome (77.1/50.0%), and humeroscapular periarthritis (59.1/39.5%). Significant treatment effects in favor of PRI vs. placebo were seen in patients with cervicobrachial syndrome (OR: 3.37, 95% CI: 1.72–6.59; p < .001, NNT: 3.7), and spondylosis deformans (OR: 3.29, p = .014, NNT: 4.3), whereas effects reported for patients with humeroscapular periarthritis were insignificant (OR: 2.21, 95% CI: 0.94–5.21; p = .068, NNT: 5.1).