China
Africa
Explore chapters and articles related to this topic
Vitreoretinal
Published in Mostafa Khalil, Omar Kouli, The Duke Elder Exam of Ophthalmology, 2019
Neovascularization leading to haemorrhage Diabetic retinopathy.Sickle cell retinopathy.ROP.Wet ARMD.Retinal vein occlusion.
High Systolic Blood Pressure, Anterior Segment Changes and Visual Impairment Independently Predict Sickle Cell Retinopathy
Published in Hemoglobin, 2021
Ibrahim M. Idris, Aminu A. Yusuf, Dalha H. Gwarzo, Musbahu S. Kurawa, Abdulsalam Shuaib, Aisha A. Galadanci, Hauwa Ibrahim, Awwal M. Borodo, Yusuf D. Jobbi, Maryam B. Danagundi, Sakinatu B. Borodo, Idris Y. Mohammed, Najibah A. Galadanci, Aisha Kuliya-Gwarzo
Despite the high prevalence of sickle cell disease in sub-Saharan Africa, where 75.0% of the global burden occurs, there is a paucity of data on sickle cell disease-related eye complications, including retinopathy. The risk factors for eye complications in the high-risk patient population with sickle cell disease have not been adequately investigated. Thus, some of the potential blindness complications of sickle cell disease go unrecognized by both the patients and their care providers. Additionally, the clinical and laboratory risk factors of sickle cell disease-related retinopathy need to be systematically explored in resource-limited settings such as Nigeria, with a high burden of sickle cell disease. As part of our efforts to address some of the literature gaps about sickle cell disease-related eye complications, we designed the Retinopathy in Sickle Cell Anemia (RETSCAN) study, which has both cross-sectional and longitudinal phases. In this phase of the study, we aimed to estimate the prevalence of sickle cell retinopathy and its potential predictors.
Ocular Manifestations of Sickle Cell Disease in Different Genotypes
Published in Ophthalmic Epidemiology, 2021
Saif Aldeen AlRyalat, Bahaa Al-Din Mustafa Jaber, Abdulaziz A. Alzarea, Abdullah A. Alzarea, Wejdan A. alosaimi, Mouna Al Saad
Sickle cell disease (SCD) is a multisystemic disorder caused by a single gene mutation, causing red blood cells to assume a rigid sickle shape under certain circumstances.1 The most common variants in sickle cell disease are the homozygous SS and the heterozygous SC genotypes. These variants are caused by the presence of either 2 copies of the mutated hemoglobin S (HbS) allele, or a one copy of the HbS allele and another hemoglobin C (HbC) allele.2 Generally, patients with HbS homozygous genotype exhibit clinically more severe complications compared to other genetic variants,1 this logical finding was contradicted by a paradox that the SC genotype exhibits higher incidence of retinitis proliferans, osteonecrosis, and acute chest syndrome.3 Although sickle cell disease can affect any part of the eye, it mainly targets the conjunctiva, manifesting as characteristic comma-shaped conjunctival vessels known as “conjunctival sign”,4 the iris, manifesting as iris atrophy,5 and the retina where it is classified into proliferative and non-proliferative sickle cell retinopathy.1
Ocular Manifestations of Sickle Cell Disease: Signs, Symptoms and Complications
Published in Ophthalmic Epidemiology, 2020
Saif Aldeen AlRyalat, Mohammed Nawaiseh, Barakat Aladwan, Allaa Roto, Zeyad Alessa, Akram Al-Omar
Most patients with sickle cell disease, regardless of the genotype, maintain good visual acuity because the associated structural changes of the retina that occur in proliferative sickle cell retinopathy are located peripherally as the novel retinal imaging techniques disclose.6 While many studies have assessed ocular manifestations of sickle cell disease, none have assessed the most common manifestations or complications in such a large sample. In this study, we aim to assess the frequency of different ocular signs, symptoms and complications of sickle cell disease.