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Green Synthesis of Nanoparticles and Their Antimicrobial Efficacy against Drug-Resistant Staphylococcus aureus
Published in Richard L. K. Glover, Daniel Nyanganyura, Rofhiwa Bridget Mulaudzi, Maluta Steven Mufamadi, Green Synthesis in Nanomedicine and Human Health, 2021
Nonhlanhla Tlotleng, Marian Jiya John, Dumisile W. Nyembe, Wells Utembe
Maqbool et al. (2016) showed the efficacy of green-synthesized cerium dioxide (CeO2) NPs against S. aureus. The 24-nm CeO2-NPs synthesized using Olea europaea leaf extract showed antibacterial activity against both gram-negative and gram-positive (S. aureus) bacteria. The addition of CeO2-NPs (20 µg/5 µl) resulted in moderate antibacterial activity at a ZOI of 9, 10 and 8 mm, respectively. Green-synthesized nickel oxide (NiO) NPs also showed potential biomedical application (Ezhilarasi et al., 2016). The spherical-shaped NiO-NPs with a size of 9.69 nm were synthesized using Moringa oleifera plant extract. In this study, NiO-NPs were found to be more effective against gram-positive S. aureus (ZOI 15 mm) than gram-negative bacteria.
Inhalation Toxicity of Metal Particles and Vapors
Published in Jacob Loke, Pathophysiology and Treatment of Inhalation Injuries, 2020
Epidemiologic studies among nickel refinery workers (NAS, 1975) and experimental studies in laboratory rodents have established Ni carcinogenesis in man and animals. Respirable particles of Ni, Ni subsulfide, nickel oxide, and vapors of nickel carbonyl are primarily responsible for Ni carcinogenicity. The highest risk of mortality from cancer of the respiratory tract is found among nickel mine workers involved in roasting, smelting, and electrolysis. Pulmonary carcinomas have been induced in rodents following the inhalation of nickel dust (particle size 4 μm) (Heuper, 1958) and following nickel carbonyl inhalation (Sunderman et al., 1959). Carcinogenic synergism between Ni compounds and polycyclic aromatic hydrocarbons, such as benzpyrene, has been established in rats (Maenza et al., 1971).
Experimental Lung Carcinogenesis by Intratracheal Instillation
Published in Joan Gil, Models of Lung Disease, 2020
Inhalation of nickel subsulfide showed carcinogenic effects in the rat lung (Ottolenghi et al., 1974). It has also been suggested that nickel carbonyl induces lung tumors in rats (Sunderman et al., 1959). Rats exposed to nickel powder (Hueper, 1958; Hueper and Payne, 1962) or nickel oxide (Takenaka et al., 1985) developed no lung tumors. Wehner et al. (1975b) observed no lung tumors in Syrian golden hamsters following inhalation of nickel oxide.
Lung toxicity profile of inhaled copper-nickel welding fume in A/J mice
Published in Inhalation Toxicology, 2022
Patti C. Zeidler-Erdely, Aaron Erdely, Vamsi Kodali, Ronnee Andrews, James Antonini, Taylor Trainor-DeArmitt, Rebecca Salmen, Lori Battelli, Lindsay Grose, Michael Kashon, Samantha Service, Walter McKinney, Samuel Stone, Lauryn Falcone
Ni represents the second largest metal component of the fume tested and is classified as carcinogenic to humans by the IARC, as supported by many worker and animal studies (IARC Working Group on the Evaluation of Carcinogenic Risk to Humans 1990; Costa 1991; Langard 1994; Shen & Zhang 1994; Antonini 2003; Kasprzak et al. 2003). Previous work by our lab has evaluated individual surrogate metal components of SS welding fume which included exposures to nickel oxide (NiO) in mice. NiO, deposited dose of up to 281 ug, caused no lung cytotoxicity, lung inflammation, or tumor promotion (Falcone et al. 2018). This dose of NiO would exceed the amount deposited in the lung in this study by more than an order of magnitude. These results suggest that the acute lung toxicity and inflammation was the result of the Cu component of the welding fume.
A T-dependent antibody response evaluation in CD-1 mice after an acute whole-body inhalation exposure to nickel (II) chloride hexahydrate
Published in Journal of Immunotoxicology, 2021
Samuel Buxton, Michael D. Taylor, Jeffrey T. Weinberg, James M. Randazzo, Vanessa L. Peachee, Adriana Oller
While an IM injection study with nickel sulfate (NiSO4) or NiCl2 showed there was induction of significant immunosuppression (decrease in plaques/106 spleen cells), a similar injection with nickel oxide (NiO) caused no immunosuppression (Graham et al. 1978). All doses of NiSO4 (3.09-12.34 µg Ni/g) led to significant decrease in plaques/106 spleen cells; for NiCl2, significant decreases in plaques/106 spleen cells were noted only at the two highest (9.25 and 12.34 µg Ni/g) and not at the two lowest (3.09 and 6.17 µg Ni/g) doses tested. Those authors speculated a role for the two anions (chloride and sulfate) in the toxicity observed. It can be inferred that the lack of effects with the insoluble NiO may be due to a low bioavailability of nickel ion (Ni2+) from this substance compared to Ni2+ from the soluble nickel salts.
Exposure to variable doses of nickel oxide nanoparticles disturbs serum biochemical parameters and oxidative stress biomarkers from vital organs of albino mice in a sex-specific manner
Published in Biomarkers, 2020
Malik Fiaz Hussain, Muhammad Naeem Ashiq, Muhammd Gulsher, Atif Akbar, Furhan Iqbal
Nickel is a metal with magnetic properties that is commonly used in food and dairy processing equipment, chemical synthesis and in petroleum industry. Coins, tableware and utensils, springs, magnets, batteries (nickel–cadmium), and spark plugs also utilize nickel alloys (Tsao et al. 2017). Nickel is naturally present in earth crust in combination with oxygen, as oxides, and with sulphur, as sulphides (Das et al. 2008). Nickel oxide (NiO) is a semiconductor and is extensively used in gas sensors, electrochromic, photocatalysts, electrocatalyst and energy devices (Cao et al. 2020). NiO NPs have specific characteristics, such as low melting point and high magnetism, reactivity and surface area (Zhang et al. 2003) due to which they are used in alloy production, electroplating and welding as well (Zaitseva et al. 2016). Occupational exposure to NiO NPs occurs in alloy production, electroplating, refining and welding (Denkhaus and Salnikow 2002). They also have biomedical applications and NiO NPs containing thin films are proven as integrated biosensors for detection of cholesterol in the serum samples (Kaur et al.2017).