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Peutz−Jeghers Syndrome
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Differential diagnoses for PJS include several hereditary tumor syndromes that show overlapping signs and symptoms with PJS, i.e. juvenile polyposis syndrome (JPS), Cowden syndrome (CS), Carney complex (CC), familial adenomatous polyposis (FAP), and hereditary nonpolyposis colorectal cancer (HNPCC) (Table 22.1) [39–42]. Other notable differential diagnosis consists of Laugier−Hunziker syndrome (LHS, presence of perioral, digit, and nailbed hyperpigmentation/lentiginosis of dark-brown to blue-black color in adults; absence of polyposis and cancer risk; lack of family history).
Pigmented nonmelanocytic skin lesions
Published in Dimitris Rigopoulos, Alexander C. Katoulis, Hyperpigmentation, 2017
Elvira Moscarella, Simonetta Piana, Caterina Longo, Giuseppe Argenziano
Laugier–Hunziker syndrome is characterized by a variable number of pigmented macules that most commonly appear on the lower lip, buccal mucosa, hard palate, and occasionally, tips of the fingers. The lesions mostly occur on the nails. This syndrome differs from Peutz–Jeghers syndrome because of the absence of intestinal polyps.7
Oral Problems Associated with Gastrointestinal Disease
Published in John F. Pohl, Christopher Jolley, Daniel Gelfond, Pediatric Gastroenterology, 2014
Single lesions should undergo excisional biopsy to rule out early melanoma. With identification of multiple lesions, a screening work-up for Peutz–Jeghers syndrome, Laugier–Hunziker syndrome, and Addison disease is required.
Laugier-Hunziker syndrome: complete clearance of mucosal lentigines with a single session of Q-Switched Nd:YAG laser
Published in Journal of Cosmetic and Laser Therapy, 2019
Pigmented spots in the oral mucosa are a common problem for which patients present to dermatologists, ENT specialists, and dentists. Laugier-Hunziker syndrome (LH syndrome) is a condition characterized by mucosal lentigines in the oral cavity with or without lentigines on acral parts of the body and longitudinal melanonychia. Laugier and Hunziker first described this condition in 1970 as a condition characterized by adult-onset oral pigmentation and sometimes similar genital lesions(1). Longitudinal melanonychia was added to the description of the syndrome a decade later(2). Clinically the condition mimics Puetz-Jeghers syndrome but it does not have a familial predisposition or malignant potential(3). Its etiology is still unknown.
A case of recurrent pigmented macules in Laugier-Hunziker syndrome treated using a Q-switched Nd-YAG laser
Published in Journal of Cosmetic and Laser Therapy, 2019
Myoung Eun Choi, Chang Jin Jung, Woo Jin Lee, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Seung Hwan Paik
Laugier-Hunziker syndrome (LHS) is a sporadically acquired melanotic pigmentation of the lips and oral mucosa, causing cosmetic distress. Although several methods of treatments have been reported, long-term follow-up data on recurrences after treatment are lacking in these patients. Our present case indicates that new macules can recur even several years after laser treatment but that they remain equally responsive to the same laser therapy.