Acute basophilic leukemia

Acute Leukemia and Myelodysplastic Syndromes

Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019

Mark D. Brissette, James D. Cotelingam

Acute basophilic leukemia is AML with basophil precursors. This is a newly described entity, and the incidence is not known with certainty. These cases resemble M2, but some blasts contain basophilic granules in their cytoplasm. By EM, the granules are immature basophil granules, theta granules, and/or immature mast cell granules. They can be seen in blasts that do not have granules by light microscopy. Cytogenetic associations are ill defined.

c-MYB and DMTF1 in Cancer

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Journal Information

Published in Cancer Investigation, 2019

Elizabeth A. Fry, Kazushi Inoue

Acute basophilic leukemia (ABL) is a rare subtype of acute leukemia with clinical features related to hyperhistaminemia because of excessive growth of basophils. Cases of t(X;6)(p11;q23) translocation have been reported in this disease (41). Quelen et al. (42) reported the four cases of ABL with a t(X;6)(p11;q23) translocation occurring in infants. The in situ hybridization and rapid amplification of cDNA ends revealed that the translocation generated a MYB-GATA1 fusion gene (42; Figure 2B). Expression of MYB-GATA1 in mouse lineage(-) cells committed them to the granulocyte lineage and blocked them at an early stage of differentiation. These results establish a link between chromosomal translocation and the development of ABL with t(X;6)(p11;q23) translocation (42).

Acute basophilic leukemia

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Acute Leukemia and Myelodysplastic Syndromes

c-MYB and DMTF1 in Cancer