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Published in Ken Addley, MCQs, MEQs and OSPEs in Occupational Medicine, 2023
The CLP Regulation (for ‘Classification, Labelling and Packaging’) is a European Union regulation from 2008 aligning the EU system of classification, labelling and packaging of chemical substances and mixtures to the Globally Harmonised System (GHS). Ozone is too unstable to store and transport so does not come under the CLP Regulations. Ozone will attack and degrade rubber seals and gaskets and ozone levels tend to increase with temperature in populated areas.
Storage, Labeling, and Transport of Essential Oils
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
Jens Jankowski, Jens-Achim Protzen, Klaus-Dieter Protzen
In the EU Regulation (EC) No. 1272 onClassification,Labelling andPackaging of substances and mixtures, in general, often called as CLP-Regulation, was published in 2008. It is based on the Globally Harmonised System (GHS) and became binding in the EU on 2009.01.20 replacing the Regulations (EC) No. 67/548 as well as (EC) No. 1944/45 (Directive 1999/45/EC of the European Parliament and of the Council of 31 May, 1999).
Public Health Risks Posed by Waste Pollution and Chemical Exposure and Legal Responses in International and EU Law
Published in Stefania Negri, Environmental Health in International and EU Law, 2019
With specific reference to the environmental pollution from waste, the main framing effort came with the adoption of Directive (EC) 2008/98,40 better known as Waste Framework Directive, which provided for a general framework of waste management requirements and set the basic waste management definitions for the EU. The Waste Framework Directive laid down measures to protect the environment and human health by preventing or reducing the adverse impacts of the generation and management of waste and by reducing overall impacts of resource use and improving efficiency.41 This Directive was also supplemented by other acts concerning specific waste, such as the Directive on waste electrical and electronic equipment (WEEE Directive).42 With regard to chemicals that are essential for economy and daily life, the Regulation (EC) 1907/2006 introduced a system for the Registration, Evaluation, Authorisation and Restriction (REACH Regulation), also establishing a European Chemicals Agency.43 This Regulation, pursuant to the abovementioned Johannesburg Implementation Plan, established that the European Union aims to achieve that, by 2020, chemicals are produced and used in ways that lead to minimise the significant adverse effects on human health and the environment. It introduced a new system aimed at encouraging and in certain cases ensuring that substances of high concern were eventually replaced by less dangerous substances or technologies where suitable economically and technically viable alternatives are available. Additionally, this Regulation was based on the principle that industry should manufacture, import or use substances or place them on the market with such responsibility and care as may be required to ensure that, under reasonably foreseeable conditions, human health and the environment are not adversely affected.44 Together with the REACH Regulation, the so-called CLP Regulation from the acronym of Classification, Labeling and Packaging of substances and mixtures45 completed the revision of the European legislation on chemicals.
A review of 4652 exposures to liquid laundry detergent capsules reported to the United Kingdom National Poisons Information Service 2008–2018
Published in Clinical Toxicology, 2019
Rachael Day, Sally M. Bradberry, Gillian Jackson, David J. Lupton, Euan A. Sandilands, Simon H. L. Thomas, John P. Thompson, J. Allister Vale
From 2013 to mid-June 2015 (the period when voluntary manufacturing changes were made but prior to amendment of the CLP regulation), there were 132 exposures involving products of an unknown identity and only two exposures involving products not made by one of the companies supporting the manufacturing changes. Hence, it is not known with certainty whether these 132 exposures were to products with modified packaging. However, during the latter part of 2015 through 2018, once the manufacturing changes had been made mandatory, all 107 exposures involving products of an unknown identity should have complied with the new CLP regulation. Therefore, it is probable that at least 97.0% of all pediatric exposures in this study involved products that complied with the voluntary and mandatory manufacturing changes.
MAGAM II – prospective observational multicentre poisons centres study on eye exposures caused by cleaning products
Published in Clinical Toxicology, 2019
Maren Hermanns-Clausen, Herbert Desel, Elke Färber, Carola Seidel, Angelika Holzer, Florian Eyer, Antje Engel, Dagmar Prasa, Erol Tutdibi, Andreas Stürer
Compared to other chemical products, cleaning product exposures are frequently reported to poisons centres (PC) in western countries [1,2]. Between 7.6% and 9.1% of human exposures reported to PCs are caused by cleaning agents (household) [2,3]. Ingestions dominate (75.8%), whereas other routes of exposure such as ocular (8.4%), inhalation (6.9%), and dermal routes (3.1%) are less common [3]. The eye is particularly vulnerable, and exposure to chemical products can cause severe eye injury. Alkaline agents penetrate more deeply than acids (with the exception of hydrofluoric acid), thus causing severe damage to the ocular surface [4,5]. EU Chemicals Legislation on Classification and Labelling (Regulation (EC) No 1272/2008, CLP Regulation) is – among other objectives – intended to better prevent irreversible eye effects by classifying mixtures more appropriately (eye category I) than in the past leading to labelling many products with Hazard Phrase H318 “causes serious eye damage”. The objective of this study was to identify cleaning products with the potential for irreversible eye damage by collecting and following-up human exposures reported to poisons centres.
Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution
Published in Critical Reviews in Toxicology, 2018
S. Rotter, A. Beronius, A. R. Boobis, A. Hanberg, J. van Klaveren, M. Luijten, K. Machera, D. Nikolopoulou, H. van der Voet, J. Zilliacus, R. Solecki
Within the EU, the placing of chemical substances and products on the market is highly regulated in order to ensure a high level of protection for human health. For the registration, evaluation, authorization and restriction of chemicals (REACH) within the scope of Regulation EC (2006), all obligations are related to substances (i.e. products of manufacturing processes) and no separate requirements or guidance for the hazard and risk assessment of combined exposure to multiple chemicals is provided (Kortenkamp et al. 2009; CEFIC 2010). The REACH guidance document addresses aggregate exposure of single substances for consumers (ECHA 2016). In contrast, clear criteria for classification of both substances and intentional mixtures (i.e. products that, as marketed, contain more than one chemical substance) are laid down in the Classification, Labelling and Packaging (CLP) Regulation (EC 2008a), where “available information on synergistic and antagonistic effects should be taken into account for the classification of mixtures” (Recital 37). The CLP Regulation provides guidance on the hazard classification of such chemical mixtures and proposes four classification methods, depending on the available data and on the properties of the components of the mixture (ECHA 2017).