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Endocrine Disorders, Contraception, and Hormone Therapy during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Nonmalignant abnormalities, especially adenosis, are common among the daughters of pregnant women who were treated with diethylstilbestrol. Gross structural abnormalities of the cervix or vagina are identified in about one quarter and abnormalities of the vaginal epithelium in one-third to one-half of women whose mothers took diethylstilbestrol during gestation (Bibbo, 1979; Herbst et al., 1978; Robboy et al., 1984; Stillman, 1982). T-shaped uterus, constricting bands of the uterine cavity, uterine hypoplasia, or paraovarian cysts also occur with increased frequency among females exposed in utero (Kaufman et al., 1984). Among males exposed to DES in utero, epididymal cysts, hypoplastic testes, and cryptorchidism are reported with increased frequency (Stillman, 1982). Preterm delivery, spontaneous abortions, and ectopic pregnancy occurred with increased frequency in females whose mothers took diethylstilbestrol during gestation (Barnes et al., 1980; Herbst, 1981).
Periods
Published in Keith Hopcroft, Vincent Forte, Symptom Sorter, 2020
RARE uterine malformationimperforate hymenuterine hypoplasiacervical stenosispsychogenic
Long-Term Effects of Perinatal Treatment with Sex Steroids and Related Substances on Reproductive Organs of Female Mice
Published in Takao Mori, Hiroshi Nagasawa, Toxicity of Hormones in Perinatal Life, 2020
John-Gunnar Forsberg, Taisen Iguchi
Decreased responsiveness to the growth-promoting effects of estrogens and the consequent functional disturbances have been reported in the mouse uterus exposed perinatally to natural estrogens or DES.71,82-85 Uterine hypoplasia associated with suppression of gland formation in mice exposed to DES prenatally is found after maturation of the animals.24, 30, 83, 85 Similar lesions, involving suppression of uterine growth, secretory function, and cellular differentiation, are noted in women prenatally exposed to DES.86 Tensile strength (rigidity) of the uterus is also decreased in DES-exposed mice. Cytosolic and nuclear estrogen receptor sites are markedly reduced.72,87 Since the binding affinity of estrogen receptors in such animals is not different from that in the controls, this reduction must be due to quantitative rather than qualitative changes in estrogen receptor protein.87 Uterine growth associated with genesis of uterine glands is also suppressed in mice treated neonatally with tamoxifen.41
Perrault syndrome with amenorrhea, infertility, Tarlov cyst, and degenerative disc
Published in Gynecological Endocrinology, 2019
Dania Al-Jaroudi, Saed Enabi, Malak Sameer AlThagafi
To our knowledge, uterine hypoplasia, ovarian dysgenesis, Tarlov cysts, and degenerative changes of the vertebral column caused by the pathogenic mutation of LARS2 have not been reported. This is of an importance since different anomalies may be associated with specific disease syndromes. This highlights the importance of both genetic evaluation and genetic counseling for patients with congenital anomalies and rare disorders.