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SBA Questions
Published in Justin C. Konje, Complete Revision Guide for MRCOG Part 2, 2019
A 30-year-old woman attends at 12 weeks for a nuchal translucency measurement as part screening for aneuploidy. What approximate detection rate for trisomy 21 using nuchal translucency alone will you quote to this woman?77%80%87%90%93%
Maternal–fetal medicine for the neonatologist
Published in Janet M Rennie, Giles S Kendall, A Manual of Neonatal Intensive Care, 2013
Janet M Rennie, Giles S Kendall
In the first trimester the currently recommended screening test for Down syndrome includes tests of free beta-human chorionic gonadotrophin (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A), measured between 11 weeks 0 days and 13 weeks 6 days of pregnancy, combined with nuchal translucency (see below). In the second trimester (15–20 weeks) AFP and free beta-hCG is used to screen for Down syndrome. An integrated test combines the results of PAPP-A in the first trimester and beta-hCG, unconjugated oestriol and AFP between 15 and 20 weeks. This test requires two visits and the results can be combined with nuchal translucency measurement.
Diabetes in Pregnancy
Published in Emmanuel Opara, NUTRITION and DIABETES, 2005
Absolute knowledge of gestational age is required to manage the diabetic gravida, and transvaginal ultrasound assessment of crown-rump length by 11 weeks should be used whenever there is any doubt about the current length of gestation. Nuchal translucency measurement between 11 and 14 weeks can be an early warning of cardiac defects in the embryo when there is evidence that poor glycemic control was present at the time of organogenesis.
Evaluation of pre-test counselling offered for non-invasive prenatal testing (NIPT) as a primary screening tool
Published in Journal of Obstetrics and Gynaecology, 2023
Ho Yin Diana Lee, Lin Wai Chan
Within the study group, the question with the highest correct answer came from their understanding of the main aim of NIPT to screen for common trisomies such as T21 (113/116, 97%) and T18 (103/116, 88.8%). However, there were areas of knowledge deficits identified. About 44% (51/116) of them misunderstood that NIPT can identify more conditions than invasive prenatal testing and 69.8% (81/116) were unaware of the recommended need for nuchal translucency measurement prior to NIPT. Nearly half of the participants were unaware of the possibility of incidental findings (52.6%, 61/116) and reporting no results (45.7%, 53/116) with NIPT.
The effect of maternal vitamin D levels on placental shear wave elastography findings in the first trimester
Published in Journal of Obstetrics and Gynaecology, 2021
Burcu Artunc-Ulkumen, Kenan Kirteke, Faik Mumtaz Koyuncu
Blood samples were taken from the antecubital vein on the day of NT (nuchal translucency) measurement. Maternal serum PAPP-A (Pregnancy‐associated plasma protein A), free β-HCG (human chorionic gonadotropin) and Vitamin D levels were measured on the same day using commercial kits available in the hospital. Vitamin D deficiency was defined as 25(OH)D <20 ng/mL (<50 nmol/L) (Holick et al. 2011). Group I consisted of 51 pregnancies with Vitamin D deficiency (<20 ng/mL), while Group II consisted of 23 pregnancies with maternal Vitamin D levels ≥20 ng/mL.
Determinants associated with making prenatal screening decisions in a national study
Published in Journal of Obstetrics and Gynaecology, 2019
Shelly Bakst, Orly Romano-Zelekha, Jenny Ostrovsky, Tamy Shohat
The results of the multivariate analyses (Table 2) showed that for Jews, the following significant predictors of nuchal translucency measurement were: being agreeable towards the idea of abortion, having supplementary insurance, being secular, having positive views on screening, and fewer children. Subsequent analyses for Arabs (Table 3) indicated (in descending order), that acceptance of the option of abortion, having higher monthly income, supplemental insurance, and being secular were significantly related with nuchal translucency use.