Multifocal motor neuropathy

Multifocal motor neuropathy (MMN) is an autoimmune disease characterized by slowly progressive, asymmetric weakness in the upper limbs, which may resemble the lower motor neurone variant of motor neurone disease. MMN is potentially treatable with immunotherapy and is thought to be caused by focal demyelination affecting multiple nerves, especially in their proximal segments. The disease is often associated with the presence of anti-GM1 antibodies and minimal or no atrophy early in the course, with normal or reduced reflexes and no sensory findings. MMN can lead to severe and progressive disability.From: Clinical Neurology, 3Ed [2019], Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report [2023], Myeloma [2019], Amyotrophic Lateral Sclerosis [2019]

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Published in James W. Albers, Stanley Berent, Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives, 2005

James W. Albers, Stanley Berent

The neurologic symptoms and signs were long-standing and chronic, involving the peripheral nervous system in a multifocal distribution confined to individual peripheral nerves. The most likely diagnosis was thought to be an idiopathic multifocal motor neuropathy (MMN) with conduction block (Feldman, Bromberg, Albers, & Pestronk, 1991; Lange, Parry, & Trojaborg, 1993). Other items in the initial differential diagnosis included multiple entrapment neuropathies, hereditary neuropathy with liability to pressure palsy (HNLPP) (Felice, Poole, Blaivas, & Albers, 1994), mononeuritis multiplex secondary to vasculitis (Fauci, Haynes, & Katz, 1978; Kissel, 1989), Kennedy disease, and motor neuron disease of the progressive muscular atrophy type.

Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report

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Published in British Journal of Neurosurgery, 2023

Vladimir Baščarević, Dragoslav Sokić, Aleksandar J. Ristić

Multifocal motor neuropathy (MMN) is an autoimmune disease which is characterized by slowly progressive, asymmetric and predominantly distal weakness in the upper limbs with potentially severe and progressive disability.3 Reported prevalence ranges from 0.29 to 0.70 per 100 000.4

Multifocal motor neuropathy

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Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report