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Naturopathic Medicine and the Prevention and Treatment of Cardiovascular Disease
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
In medicine, there are many ways to achieve an outcome. We find that practicing individualized medicine is the foundation for optimal health. Every patient is different due to genetics, diet and lifestyle choices, co-morbidities, stress, overall toxic burden, gender, age, and other factors. Empower your patients by increasing their awareness and consciousness about health. Teach your patients about healthy diet and lifestyle measures, mind-body medicines including breathing and meditation, nutraceuticals, botanical medicines, therapeutic fasting, detoxification techniques, and grounding. All of these modalities will strengthen your practice as more and more people are searching for non-pharmacological ways to stay healthy. Remember to spend time with your patients, ask questions about their current and past health, listen to their concerns, and investigate the true cause of their suffering.
Precision Medicine
Published in Paul Cerrato, John Halamka, Reinventing Clinical Decision Support, 2020
Regardless of the words we use to describe precision/personalized/individualized medicine, all the evidence points us to a future that will reinvent clinical decision support and transform patient care in ways that are hard to imagine even today.
Drug Products with Multiple Components—Development of TCM
Published in Shein-Chung Chow, Innovative Statistics in Regulatory Science, 2019
TCM prescriptions typically consist of a combination of several components. The combination is usually determined based on the medical theory of global dynamic balance (or harmony) among organs, and the observations from the Chinese diagnostic procedure. The use of Chinese diagnostic procedure is to find out what caused the imbalance among these organs. The treatment is to re-install the balance among these organs. Thus, the dose and treatment duration are flexible in order to achieve the balance. This concept leads to the concept of the so-called personalized (or individualized) medicine, which minimizes intra-subject variability.
Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin
Published in Expert Review of Clinical Pharmacology, 2022
Shaoqian Li, Bo Xu, Shangzhi Fan, Bo Kang, Lijing Deng, Danjun Chen, Bo Yang, Fan Tang, Zunbo He, Yong Xue, Jie-Can Zhou
In recent years, several studies have been conducted on the influence of gene polymorphism on drug effectiveness, which provides new methods and new ideas of individualized medicine. As a first-line drug for diabetes, the clinical application of metformin must be given considerable attention. Multiple transporters are involved in the absorption, distribution and excretion of metformin in vivo. The effect of transporter genetic polymorphism on metformin reaction has been reported inconsistently; thus, further investigation is necessary. The development of pharmacogenomics has provided insights into the effect of metformin’s target proteins on its efficacy. In addition, studies on the polymorphism of upstream and downstream target proteins in the AMPK pathway have provided new insights into the individualized use of metformin. However, studies on the target proteins of metformin outside the AMPK pathway remain unclear and lack critical evidence, which requires further study. The study on the pharmacokinetic and pharmacodynamic gene polymorphisms of metformin can promote the rational and clinical use of metformin, improve the potency and prevent the risk of adverse repercussions.
Intervention of 3D printing in health care: transformation for sustainable development
Published in Expert Opinion on Drug Delivery, 2021
Sujit Kumar Debnath, Monalisha Debnath, Rohit Srivastava, Abdelwahab Omri
Built on the conceptual understanding of 3D printing, four-dimensional (4D) printing has been introduced recently. This novel smart technology exhibits a predetermined change upon exposure to a certain stimulus. Therefore, more researches need to focus on 4D printing in the development of smart products. 3D printing is a time-consuming process for fulfilling personal needs. Therefore, there is an emerging need to develop a newer 3D printing machine that would fabricate the formulation in a short span with a single step. The key success of any manufacturing innovation is depending on the production efficiency and patient benefit. This 3D printing has an impressive track record in the fabrication of prototyping applications. The necessary equipment can easily be installed and operate in diverse settings like pharmacies, and point of care locations including residential care facilities and hospitals. Shortly, the potential application of this technology can be seen in a clinical setting where patients will get individualized medicine as per their needs.
Assessment of spatial neglect in clinical practice: A nationwide survey
Published in Neuropsychological Rehabilitation, 2021
Lars Evald, Inge Wilms, Maria Nordfang
The main concern about the results of this survey is that the assessment of SN seems to be insufficient and biased towards the education and tradition of the professionals conducting the assessment. The consequence may be missing, incomplete or wrong diagnoses of neglect and differential symptoms expressing behaviour similar to neglect. Without proper and commonly agreed upon assessment methods, the subsequent planning and execution of treatment and therapy will suffer. Although the term individualized medicine has arisen from the tailored delivery of drug therapy based on genetic and epigenetic assessment, something similar is at stake here. The delivery of neurorehabilitation tailored to the individual patient and targeted at specific subtypes and differential diagnosis of SN is paramount. Future research on improved subtype and differential diagnosis should allow clinicians to offer more individualized and targeted rehabilitation strategies by taking into account the underlying deficits and areas of spared function (Rode et al., 2017).