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Physical Aspects of the Sex Response
Published in Philipa A Brough, Margaret Denman, Introduction to Psychosexual Medicine, 2019
Derived from the Greek eros ‘love’ and English genous ‘producing’, these zones are defined as body surface areas with heightened sensitivity which, when stimulated, may create a sexual response. Erogenous zones are classified as being either specific or non-specific and sensitivity depends upon the concentration of nerve endings at a given site.
Coronary stenting I: Intracoronary stents – Form and function
Published in Ever D. Grech, Practical Interventional Cardiology, 2017
Varinder K Randhawa, Patrick Teefy
The Genous bioengineered Cobalt Chromium (CoCr) stent is an example of a biologically coated stent. This structure combines thin stent struts (80 μm), dual helix design. The unique feature is the incorporation of endothelial progenitor cells (EPCs) capture technology utilising anti-CD34 antibodies on the stent surface. EPCs promote healing through accelerated endothelial regeneration. The new Combo stent combines an abluminal bioresorbable polymer combined with sirolimus and luminal EPC capturing technology mounted on a dual helical stent design. The REMEDEE Registry involving 1000 patients was reported at the Transcatheter Cardiovascular Therapeutics meeting in San Francisco on 11–15 October 2015. It was designed to evaluate the COMBO Dual Therapy Stent for the treatment of coronary lesions in the routine clinical care. One-year target lesion failure was 5.7%, including 1.7% cardiac death, 0.7% target vessel myocardial infarction and 4.4% ischemia-driven target lesion revascularisation. The stent thrombosis rate was low at 0.6%, which tended to occur early.
Conceptual Framework
Published in Raymond Struyk, Harold Katsura, Aging at Home, 1988
Raymond Struyk, Harold Katsura
a desired, equilibrium adjusting. Partial and served by those makis due to prior or con-;rmine the demand for ierences between Y* genous factors, which it the effects of many ;e of time. That is, an critical value. )del can be written as: . . XlQ), where P(d) is made (similar to prob-ty literature). ^ is the e end. C^is the condi-The independent vari-period rather than as )d for convenience. In repair activity under-:pairs (i.e., AY < 0) come, i.e., X,., < X,.2 pairs (AY > 0) might ciation of major coming replacement. I will provide insights i determinant and the f the change increases
Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease
Published in Journal of Immunotoxicology, 2019
Katherine A. Roach, Aleksandr B. Stefaniak, Jenny R. Roberts
Contrarily, surface adsorption of macromolecules may alter the biological activity of metal nanomaterials in a manner that is dependent on the adsorbed constituent profile. Endo-genous proteins, including immunoglobulins, cytokines, and complement proteins are all constituents of the serum and lung lining fluid known to bind metal nanomaterial surfaces (Neagu et al. 2017). The binding of complement protein C3b and IgG to nanomaterial surfaces has been shown to confer recognition by complement and Fc receptors, accelerating clearance by phagocytes, and limiting the potential of the nanomaterial to induce other immune effects (Beduneau et al. 2009; Moghimi et al. 2012; Frohlich 2015). Adsorption of exogenous agents can also lead to alterations in nanomaterial immunogenicity. One of the most notable examples is endotoxin (LPS), a frequent microbial contaminant of nanomaterial surfaces that is capable of activating innate immune cells, and inducing pro-inflammatory signaling via the TLR-4 pathway. Adsorption of LPS to nanomaterial surfaces has been shown to enhance inflammatory responses to many metal nanomaterials by lung epithelial cells, and various immune cells (Shi et al. 2010; Liu et al. 2012; Bianchi et al. 2017; Li et al. 2017; Ko et al. 2018). The chemical structure of LPS favors its adsorption to hydrophobic, positively-charged metal nanomaterial surfaces, indicating a role for physicochemical properties such as surface modification in the propensity for associations with immunogenic exogenous molecules such as LPS (Gorbet and Sefton 2005; Li et al. 2017).
The evolution of coronary stents
Published in Expert Review of Cardiovascular Therapy, 2018
Peter McKavanagh, George Zawadowski, Naveed Ahmed, Michael Kutryk
An attractive alternative to the use of DES is endothelial progenitor cell (EPC) capture stents, which have pro-healing properties and can theoretically reduce ISR and ST. Early work found that EPC cells are expressed of the surface antigen CD34, and promote re-endothelialization after balloon induced vessel wall damage [112,113]. EPC cell levels are low in the circulation, and as such recruiting them to the stent surface fosters endothelialisation and prevents thrombus formation. The Genous stent (OrbusNeich Medical Technologies, Fort Lauderdale, FL, USA) has a monoclonal CD34 antibody in a proprietary polysaccharide intermediate coating that binds EPC from the peripheral blood, thus providing the stent with its pro-healing properties.
Water-soluble porphyrin-PAMAM-conjugates of melphalan and their anticancer activity
Published in Drug Development and Industrial Pharmacy, 2018
Julio César Ramírez-Arroniz, Elena Martínez Klimova, Luis Daniel Pedro-Hernández, Ulises Organista-Mateos, Sandra Cortez-Maya, Teresa Ramírez-Ápan, Antonio Nieto-Camacho, José Calderón-Pardo, Marcos Martínez-García
Cancer cell lines were purchased from the National Cancer Institute (NCI, Bethesda, MD): U251 (human glioblastoma), PC-3 (human prostatic adenocarcinoma), K-562 (human chronic myelo-genous leukemia cells), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma), and SKLU-1 (human lung adenocarcinoma). The human gingival fibroblast (HGF) cell line was purchased from Sigma Aldrich. Cells were aliquoted in 96-well microtiter plates to obtain dilutions of 5000–10,000 cells per well, containing Roswell Park Memorial Institute (RPMI) 1640 growth medium with 10% fetal bovine serum and supplemented with 2 μM L-glutamine. The microtiter plates were incubated at 37 °C, 5% CO2, 95% air, and 100% relative humidity for 24 h prior to the addition of the compounds. After 24 h, two plates of each cell line were fixed with trichloroacetic acid (TCA), to measure the cell population at the time of drug addition (Time zero ‘Tz’). Stock solutions of test compounds were dissolved in water. Stocks were further diluted to the concentration of 10 µM. Following drug addition, the plates were incubated for 48 h under the same conditions mentioned above. The assay was terminated by the addition of 50 µL of cold 50% (w/v) trichloroacetic-acid and incubated for 1 h at 4 °C. Sulforhodamine (SRB) solution at 0.4% (w/v) in 1% acetic acid was added to each well. The plates were placed on a shaker for 5 min at room temperature. Absorbance was read on an Ultra Microplate Reader (Elx 808: Bio-Tek Instruments, Inc., Winooski, VT) at a wavelength of 515 nm. The percentage of growth was calculated based on Tz. The test-compounds were added at a concentration of 10 µM [27,28].