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Police and psychiatric patient encounters
Published in John A. Liebert, William J. Birnes, Psychiatric Criminology, 2016
John A. Liebert, William J. Birnes
For Administration of Medications in Extreme Anxiety Patients select from following menu: Zydis 2.5–10 mg po to prevent cheekingZyprexa 2.5–10 mg po or IMRisperdal M tabs 0.5–2 mg po to prevent cheekingRisperdal 0.5–2 mg poGeodon 5–15 mg IMSeroquel 25–50 mg poHaldol 0.5–5 mg ± Cogentin 0.5 mg ± Ativan 0.5–2 mg IM. Give in liquid form together to assure compliance or in tablet form if practicalAtivan 0.5–2 mg po may be surprisingly effective, and certainly should be considered first line when anxiety rather than dyscontrol dominates presentationAbilify 2 or 5 mg IMDroperidol IM 5 mg in younger patients who have no apparent medical surgical problems or history of cardio/respiratory disease (www.challengercme.com/Product?productid=18)
Preparation of orally fast-dissolving tablets of etilefrine hydrochloride to achieve efficient absorption
Published in Pharmaceutical Development and Technology, 2020
Although the solution dosage form (oral droplet) gave the basic absorption profiles of ET, its handling and measurement are not simple, its storage may affect the stability and spillage can be caused in the practical application. Considering these problems, solid dosage forms, such as tablets are advantageous because of their easiness at handling. From the previous findings that the wide spread of ET solution with high drug concentration is important for efficient mucosal absorption, we herein proposed that orally fast-dissolving tablets should be appropriate as a dose form. Although orally disintegrating tablets (ODTs) are originally developed to reduce the difficulties in swallowing of geriatric or pediatric patients (Bhatu et al. 2011), in this study, fast disintegration and the subsequent instantaneous dissolution are attempted to achieve rapid and efficient mucosal absorption. Seagar indicated that drug absorption from the mouth, pharynx and oesophagus routes should be caused in the fast-dissolving dosage form, Zydis (Seager 1998). In addition, ODTs, dissolved with only saliva or small water, are appropriate for the patients that fluid restriction is required to (Nagar et al. 2011). ODTs are quickly disintegrated under the mouth conditions with small fluids and the drugs are dissolved fast. Several ODTs lack of high strength in order to give the above features, though, they can be handled without harsh conditions (Bhatu et al. 2011). In such ODTs, appropriate packaging is selected. As ET is highly water-soluble, its fast-disintegrating tablets should enable its fast dissolution. Considering these situations, orally fast-dissolving tablets of ET that can be handled normally have been prepared in the simple manner, and the products have been examined in vitro and in vivo.
Advances in orally administered pharmacotherapy for the treatment of migraine
Published in Expert Opinion on Pharmacotherapy, 2019
Paolo Martelletti, Maria Adele Giamberardino
The fast-dissolving Zydis® rimegepant formulation will enable migraineurs to start their acute treatment promptly, without a need for swallowing liquids, which is particularly important considering that the vast majority of patients with migraine experience nausea or vomiting.