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Getting to grips with social services
Published in Geoff Meads, Tricia Meads, Trust in Experience, 2018
It is therefore nothing new for social services departments to be asked to participate in a joint venture with the health service. But the new PCG/T set up differs considerably from any of the previous models as it has a far wider remit and requires broader partnership working than anything previously conceived. It is not just about developing easier operational relations, it is about forming a large multi-agency organisation which plans and commissions local health services.
Tigecycline
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Tigecycline is available for i.v. use only. An oral formulation is not available because of poor oral absorption. Compatible intravenous solutions include 0.9% sodium chloride injection, USP, and 5% dextrose injection, USP. The following drugs should not be administered simultaneously with tigecycline through the same Y-Set: amphotericin B, amphotericin B lipid complex, diazepam, esomeprazole, and omeprazole (Tygacil, FDA prescribing information, side effects and uses, June 2016).
Dynamic Structural Equation Models of Change
Published in Jason T. Newsom, Richard N. Jones, Scott M. Hofer, Longitudinal Data Analysis, 2013
I next combined the latent change variable models for memory ratings and observed memory. First, I combined the two best-fitting univariate change models (spline model with τ = 70 for memory ratings and dual change model for memory). Correlations between the intercept and slope terms for both variables were included (a total of four correlations ρX0Y0, ρX0Ys ρXsY0, and ρXsYs). The values of α[t] were fixed at those estimated from the univariate model (α[t] = 0.383 for t > 70; see Table 10.2). The residuals at each time point were also allowed to correlate (ρexey) to account for common testing factors. The model fits, and estimates for the different bivariate models are provided in Table 10.3. The first model (Model a) represented the no-coupling hypothesis, with both γX and γY set to zero so that neither variable affected the other. The next model (b) represented the idea of memory performance being the leading variable with γY freely estimated and γX set to zero. The hypothesis is that memory at one time point affects changes in memory ratings 2 years later. The improvement in fit from the previous model was negligible.
Dimension-wise sparse low-rank approximation of a matrix with application to variable selection in high-dimensional integrative analyzes of association
Published in Journal of Applied Statistics, 2022
J. C. Poythress, Cheolwoo Park, Jeongyoun Ahn
In Figures 1 and 2, we show the results for some selected settings in Table 1 that highlight the main findings. The results for all of the settings can be found in Web Appendix C. Figures 1 and 2 show boxplots of the average rank of the signal variables for each method. Each figure contains the results for both sets of variables X and Y as well as both variable importance metrics. Metric 1 corresponds to the metric based on the number of times a variable was selected and Metric 2 corresponds to the metric based on the magnitudes of the loadings. For the X set, the average rank of the signal variables is the average ranks of the first 20 variables for settings with 90% sparsity or the first 10 variables for the setting with 95% sparsity. The best possible average rank (assuming no ties) of the X signal variables is 10.5 for 90% sparsity and 5.5 for 95% sparsity. For the Y set, the average rank of the signal variables is the average ranks of the first 16 variables for settings with 90% sparsity or the first 8 variables for the setting with 95% sparsity. The best possible average rank of the Y signal variables is 8.5 for 90% sparsity and 4.5 for 95% sparsity.
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress
Published in Expert Opinion on Therapeutic Targets, 2022
Ernestina Marianna De Francesco, Francesca Cirillo, Veronica Vella, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano
TNBC is extremely heterogeneous at the clinical, histologic, and molecular level. It is characterized by cancer progression independent of estrogen, progesterone, and human epidermal growth factor 2 protein (HER2) and is 10–20% more common in overweight compared with normal-weight women [9]. According to the gene-expression profile, TNBC has been classified into six subtypes, namely basal-like subtypes (BL1 and BL2), mesenchymal (M), mesenchymal stem-like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR) [10]. A more recent classification, complemental to the previous one, divided TNBC into four subclasses: i) LAR, which expresses cell-surface mucin MUC1 besides AR; ii) M, expressing the platelet-derived growth factor receptor (PDGFR) and c-Kit receptor; iii) basal-like immunosuppressed (BLIS), which expresses the immunosuppressive molecule VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1); iv) basal-like immune-activated (BLIA), characterized by the up-regulation of immune regulatory pathways and the expression of STAT genes [11]. Furthermore, Liu and collaborators divided TNBC into four different subtypes (IM, LAR, M, and BLIS) based on the messenger RNA (mRNA) and long non-coding RNA (lncRNA) expression [12]. This huge heterogeneity contributes to limit its therapeutic options. Moreover, the diagnosis is challenging due to the molecular overlap between the TNBC phenotype and the basal-like subtype of BC, resulting in the subsequent idea that they are the same entity.
Comparative effectiveness of lactulose and sennosides for the prevention of peritoneal dialysis-related peritonitis: an open-label, randomized, active-controlled trial
Published in Annals of Medicine, 2021
Kajohnsak Noppakun, Tichanun Narongchai, Romanee Chaiwarith, Uraiwan Wongsawad, Surachet Vongsanim, Chidchanok Ruengorn, Surapon Nochaiwong
All the participants in this trial were administered intravenous antibiotics at the time of PD catheter insertion, using the Y-set and double-bag systems, and using conventional glucose-based solutions. Routine exit-site care with prophylactic antimicrobial agents was not adopted in our PD setting owing to concerns regarding the emergence of resistance to antimicrobial agents. However, all the participants and their caregivers in this trial were trained with a standard program for daily exit-site care with normal saline dressing along with sterile techniques focussing on hand hygiene and mask-wearing during PD bag exchange. Adherence to interventions and concomitant medications as a part of standard PD treatment was recorded and monitored by direct observation of the participants and their caregivers, and by counting the quantity of assigned medication on each follow-up visit. Treatment adherence was defined as more than 80% of the participants taking the assigned medication.