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Bio-Implants Derived from Biocompatible and Biodegradable Biopolymeric Materials
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
Polymer characterization can use mass spectrometry (MS) which provides details of the development of ionization techniques like MALDI and ESI combined with the latest developments in mass analyzers such as reflection-TOF and FTICR. This has greatly enhanced the capabilities of MS to better understand the detailed composition of polymeric materials. These techniques are giving better mass resolution and accuracy along with hyphenated techniques, also give better details about the smallest components in polymeric biomaterials to be assessed, especially with regard to the composition of repeat and end groups. Maziarz and coworkers [22, 23] review the applications of MS in the characterization of polymeric biomaterials.
Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
Published in Drug Delivery, 2018
Cristina Fornaguera, Miguel Ángel Lázaro, Pau Brugada-Vilà, Irene Porcar, Ingrid Morera, Marta Guerra-Rebollo, Cristina Garrido, Núria Rubio, Jerónimo Blanco, Anna Cascante, Salvador Borrós
Polymer P was also used for the synthesis of the co-polymer 2 P (Figure 1(C)), by covalently attaching the peptide targeting sequence, as described in Section 2. Similar to polymer P, to confirm that a polymer 2 P batch was appropriate, it had to fulfill the specifications detailed in Figure 1(D) (see results of 2 P co-polymer characterization in Supplementary Table S2); in particular two parameters were determined by 1 H-NMR: polyester peaks and peptide peaks (see an example of 1 H-NMR spectra on Supplementary Figure S4). These properties were maintained for at least six weeks at −20 °C, thus confirming the stability of this frozen polymer (Explanation S7, Supplementary material). In addition, no new peaks were detected.