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Resveratrol-Loaded Phytomedicines for Management of Cancer
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Shakir Saleem, Ruqaiyah Khan, Sandeep Arora
Some of the research studies have recorded intense toxicity of curcumin-loaded poloxamer nanocarriers in HeLa (Sahu et al., 2011) and ovarian cancer cells (Saxena et al., 2013). Moreover, resveratrol and doxorubicin (DOX) containing poloxamer nano-formulations exhibited a synergistic effect on ovarian cancer in mice (Carlson et al., 2014). Kim et al. (2015) reported that a combination of resveratrol-quercetin elucidated similar effect in ovarian tumors (Kim et al., 2015). In addition, resveratrol was encapsulated into PEG-polycaprolactone conjugate was used to encapsulate resveratrol and the surface modification of the resulting micelles was carried out using a polipoprotein and used to treat glioblastoma (Wang et al., 2015) as well as breast cancer. Finally, other studies mentioned that epigallocatechin gallate (EGCG) was delivered in colon cancer using PEG-polylactic acid (PLA) (Haratifar et al., 2014) and in pancreatic cancer using casein micelles as carriers (Sun et al., 2014) (see Table 12.5).
Application of Bioresponsive Polymers in Drug Delivery
Published in Deepa H. Patel, Bioresponsive Polymers, 2020
Manisha Lalan, Deepti Jani, Pratiksha Trivedi, Deepa H. Patel
It is practically impossible for the hydrophilic molecules to gain entry into the brain by crossing blood-brain barrier. One of the approaches for direct brain targeting is through nasal cavity. The nasal cavity offers direct transport of drugs to brain through olfactory and trigeminal nerve cells. Gabal et al. loaded anti-Parkinsonism drug, ropinirole into nanostructured lipid carriers and integrated them in Poloxamer 188 in situ gels. The system vastly improved the bioavailability by direct nose to brain transport [57]. Another study on thermoresposnsive polymers for nose-to-brain delivery was for 32P-siRNA dendriplexes [58]. Poloxamer 407 along with muco-adhesives, carbopol, and CS were employed in formulation. Radiological studies confirmed the delivery of cargo in brain and showed better brain localization than intravenous or intranasal buffered administration. Another study in the same direction by Jose et al. explored Pluronic based thermo-sensitive hydrogels containing CS microspheres for direct nose to brain transport of lorazepam. The designed system gave sustained release of drug and was biocompatible also [59].
Lipid-Based Nanoparticles: SLN, NLC, and MAD
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Rita Cortesi, Paolo Mariani, Markus Drechsler, Elisabetta Esposito
Poloxamer 407 copolymer is one of the more-used surfactants. Poloxamer 407, characterized by interesting thermo-reversible behavior, is able to emulsify monoolein in water, leading to aqueous dispersions mainly composed of cubosomes, hexasomes, and vesicles mixture (Gustaffson et al., 1996, Larsson, 2000, Siekmann et al., 2002).
A thermodynamic study of F108 and F127 block copolymer interactions with liposomes at physiological temperature
Published in Journal of Liposome Research, 2022
Obed Andres Solis-Gonzalez, Juan Ramon Avendaño-Gómez, Aarón Rojas-Aguilar
Triblock copolymers, such as those in the poloxamer family, are synthetic, non-ionic, linear macromolecules with a general structure arranged in the A-B-A form (polyethylene oxide-polypropylene oxide-polyethylene oxide, PEOm-PPOn-PEOm, in which m and n represent the degrees of polymerization). The PEO chains confer hydrophilicity, and PPO confers hydrophobicity. Poloxamers have been widely applied in medical and pharmaceutical applications since they possess excellent biocapatibility or low toxicity as drug delivery agents. In this case, F108 and F127 copolymers have been used in hydrogel formulations of hyaluronic acid in arthroplastic surgeries (Nascimento et al.2018) or F127 as efficiently micelles against drug resistance cancer cells (Wang et al.2020). Also, copolymers, such as F108, have been applied to stabilise nanostructures for different applications. For example, F108 increases the in vitro stability of hollow spheres by coating lipid nanocapsules in gene delivery applied to primary hepatocytes (Morille et al.2009) and reduces phagocytosis and extends blood-circulation time in liposome nanostructures (i.e., stealth vesicles) in drug delivery (Woodle et al.1992). Also, F127 has been reported to be the least toxic of commercially available copolymers (Gilbert et al.1986). As a result, F127 is used to develop artificial skin (Nalbandian et al.1987).
Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment
Published in Drug Delivery, 2021
Dong-Hyun Kim, Thu Nhan Nguyen, Young-Min Han, Phuong Tran, Jinhyung Rho, Jae-Young Lee, Hwa-Young Son, Jeong-Sook Park
Hydrogels have been evaluated in many studies and have been shown to retain drugs in the middle ear. Thermosensitive gels made of Poloxamer 407 (P407) and Poloxamer 188 (P188) that exist in the solution state at room temperature and in gel state at body temperature, have been actively studied (Buwalda et al., 2014). Poloxamers have been studied for topical drug delivery via many routes, such as the nasal, ocular, rectal, vaginal, and transdermal routes (Mao et al., 2016). Applications in inner ear drug delivery based on thermosensitive gels have also been studied. For effective inner ear drug delivery of gentamicin, chitosan glycerophosphate hydrogel and chitosanase were used for continuous and controlled inner ear drug delivery (Lajud et al., 2013). Another study demonstrated delayed release of drugs without histologic changes in the inner ear through PLGA NPs based on chitosan/glycerophosphate (Dai et al., 2018). This combination of NPs and hydrogels is currently considered as a promising approach that provides a synergistic effect to control drug delivery to the inner ear, in which hydrogels reduce Eustachian tube clearance and prolong the residence time in the middle ear, while NPs enhance the permeability of the drug through the RWM.
c(RGDyk)-modified nanoparticles encapsulating quantum dots as a stable fluorescence probe for imaging-guided surgical resection of glioma under the auxiliary UTMD
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Qi-Long Wu, He-Lin Xu, Cui Xiong, Qing-Hua Lan, Ming-Ling Fang, Jin-Hua Cai, Hui Li, Shu-Ting Zhu, Jing-Hong Xu, Fang-Yi Tao, Cui-Tao Lu, Ying-Zheng Zhao, Bin Chen
The cellular toxicity of blank-NP, QDs, QDs-poloxamer 188 and QDs-c(RGDyk)NP was assessed using a CCK-8 kit. The blank-NP showed no toxicity in different cells and at different concentrations. This result is consistent with the reported low toxicity of poloxamer 188. In our study, the inorganic components of the QDs we used were ZnCdSe/ZnS. A high concentration of QD solution showed strong cytotoxicity after incubation for 24 h with normal cells (PC12 and HUVECs). This may be due to the instability of the QD surface coating, which exposes the CdSe core of the QDs to UV damage or air oxidation, resulting in the release of cadmium ions from the QD core; although the ZnS capping protects the core from air oxidation but not from UV damage [56,57]. The size and shape of NPs are also factors affecting cytotoxicity [58,59]. The synthesized QDs-c(RGDyk)NP exhibited weaker cytotoxicity than the QD only solution, possibly because modification of the QDs with c(RGDyk)-poloxamer 188 increases the stability of the surface coating, making release of cadmium ions more difficult.