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Development of a second-generation whole-body small-animal SPECT/MR imaging system
Published in Yi-Hwa Liu, Albert J. Sinusas, Hybrid Imaging in Cardiovascular Medicine, 2017
Benjamin M.W. Tsui, Jingyan Xu, Andrew Rittenbach, James W. Hugg, Kevin B. Parnham
An imaging bed attached to a 3-D scanning stage was constructed to position a small animal or object inside the SPECT/MR system. The assembly was mounted on an optical table as shown in Figure 3.4c for system evaluation and experimental phantom and small-animal studies outside of a magnetic field.
Performance characterization of spring actuated autoinjector devices for Emgality and Aimovig
Published in Current Medical Research and Opinion, 2020
Zhongwang Dou, Javad Eshraghi, Tianqi Guo, Jean-Christophe Veilleux, Kevin H. Duffy, Galen H. Shi, David S. Collins, Arezoo M. Ardekani, Pavlos P. Vlachos
A photo and a schematic drawing of the experimental setup are shown in Figure 3(a,b). Two sets of specially designed fixtures, consisting of an upper housing and two bottom plates, were designed and 3D-printed in-house: one for Aimaovig device and one for Emgality device. The top housing was bolted onto an optical post (410-RC, Newport) to secure the position of the autoinjector. At the same time, two bottom plates were used to elevate the autoinjector device from the optical table. The bottom plates also kept Aimovig device unlocked by pushing against the yellow safety guard. The Integrated Electronics Piezo-Electric (IEPE) array microphone was mounted separately next to the autoinjector (∼30 mm distance). The load cell was mounted on a magnetic track linear stage and faced towards the activation button on the autoinjector device. An LED light source and a light diffuser were used to achieve uniform background illumination. The total time of autoinjector exposure to the LED light was limited to less than 10 s, and the light was turned off manually after each testing to avoid heating of the drug product. A high-speed camera was positioned in front of the sample and synchronized via a delay generator. The delay generator and data acquisitions of load cell and microphone were synchronized by a modular data acquisition (DAQ) system via the Data Acquisition Toolbox in MATLAB (R2018b, MathWorks, Inc.). The microphone and the load cell were sampled at 10,240 Hz (Figure 3(c-2)). The trigger signal (Figure 3(c-3)) was also sent to a high-speed camera to capture the insertion and injection processes, respectively (see supplementary document for details). While the audio, force, and video sequences were captured, the load cell carried by the linear stage started moving towards the activation button on the unlocked autoinjector device at 5 mm/s (Figure 3(c-4)). After the device activation, the linear stage retracted back to its initial position. All tests were conducted with injections made into air in order to allow for optical access. The details of the testing instrumentation are listed in Table 2. All the testing instrumentations are calibrated and carefully tested before each experiment.