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Hydrotropic Polymer Micelles for Cancer Therapeutics
Published in Mansoor M. Amiji, Nanotechnology for Cancer Therapy, 2006
Sang Cheon Lee, Kang Moo Huh, Tooru Ooya, Kinam Park
where χsp is the interaction parameter between the solubilized drug (s) and the hydrophobic block part (p), δ is the Scatchard–Hildebrand solubility parameter of the hydrophobic block part, and Vs is the molar volume of the solubilized drug. If the χsp shows low value, the compatibility between drug and hydrophobic block part is great. By using this parameter, Gadelle et al. suggested the following mechanism for solubilization of aromatic solutes in PEO-b-PPO-b-PEO28: The addition of apolar solutes (drugs) promotes aggregation of the block copolymer molecules.The micelle core contains some water molecules.Solubilization is initially a replacement process in which water molecules are displaced from the micelle core by the drug.
Effervescence-induced amorphous solid dispersions with improved drug solubility and dissolution
Published in Pharmaceutical Development and Technology, 2023
Muralidhar Pisay, Dani Lakshman Yarlagadda, Sai Krishna Anand Vullendula, Krishnamurthy Bhat, Koteshwara Kunnatur Balasundara, Srinivas Mutalik
The in-depth knowledge of molecular interactions may be explained using the in-silico-assisted molecular dynamics (MD) tools. The MD simulations provide information about the pre-formulation and post-formulation activities. This might reduce the experimental expenditure and improve the quality (Mehta et al. 2019). In SDs, miscibility plays an important role. The MD tools help in deciding the miscibility by the Hildebrand solubility parameter (Mehta et al. 2019). The theories like Hansen’s solubility parameter (Yani et al. 2017), Flory-Huggins miscibility parameter (Li et al. 2016), and Gibb’s free energy (Jaafar et al. 2017) explain drug-carrier miscibility at room temperature even after stability.
Optimization of nutraceutical coenzyme Q10 nanoemulsion with improved skin permeability and anti-wrinkle efficiency
Published in Drug Development and Industrial Pharmacy, 2018
Eman S. El-Leithy, Amna M. Makky, Abeer M. Khattab, Doaa G. Hussein
Transcutol HP, which is used as co-surfactant in all NE formulae, has been reported as an efficient permeation enhancer [63]. Also, the IPM oil used in all NE formulae is an aliphatic ester having the ability to penetrate the skin lipid bilayers of the stratum corneum skin layers by disrupting their arrangement and orders. The IPM has lower values of Hildebrand solubility parameter (δ = 8.02), which is near to that of human skin (δ = 10.5). Thus, IPM was considered as an excellent selection for formulating the typical NE formulae [64].