China
Africa
Explore chapters and articles related to this topic
Multi-Particle Motion
Published in Rob Appleby, Graeme Burt, James Clarke, Hywel Owen, The Science and Technology of Particle Accelerators, 2020
Rob Appleby, Graeme Burt, James Clarke, Hywel Owen
The 6 GeV European Synchrotron Radiation Facility has recently been upgraded from a natural emittance of 4 nm-rad to an emittance of 0.13 nm-rad. Making sensible assumptions about the insertion device field and coupling, determine whether the ESRF output is diffraction-limited either with its old or new design. You may assume a vertical emittance of 10 pm-rad in both configurations.
3D Dosimetry in Synchrotron Radiation Therapy Techniques
Published in Ben Mijnheer, Clinical 3D Dosimetry in Modern Radiation Therapy, 2017
A third generation synchrotron source at ESRF provides a quasi-nondiverging beam with a very high intensity photon flux, where usually a monochromatic beam with a small bandwidth is extracted, by the insertion of monochromators. Filtered “white” beams, with a broad spectrum ranging from 50 to 350 keV in the case of MRT, represent an excellent tool to determine the resolution of any suitable detector system. Monochromatic beams can also provide a tool to characterize the energy dependence of the detectors in ranges typically from 20 to 100 keV. Microbeams at the ESRF can be used for both detector development (Rosenfeld et al., 2001; Bräuer-Krisch et al., 2003; Lerch et al., 2011; Petasecca et al., 2012) and experimental studies in biology to understand the underlying processes involved in MRT (Serduc et al., 2006; Bouchet et al., 2013b; Fernandez-Palomo et al., 2013; Smith et al., 2013), with both research directions supporting the technique to move forward to phase I clinical trials.
Use of radiochromic film with synchrotron radiation
Published in Indra J. Das, Radiochromic Film, 2017
Tomas Kron, Elizabeth Kyriakou, Jeffrey C. Crosbie
The modern third-generation synchrotron facilities are spread around the globe and include the Advanced Photon Source (Chicago, USA), the European Synchrotron Radiation Facility or ESRF (Grenoble, France), and the Australian Synchrotron Facility (Melbourne, Australia) shown in Figure 19.1. These facilities maintain relativistic electrons in orbit around a storage ring that has a diameter comparable with a football stadium (110 × 50 m). Much of the research conducted at synchrotrons relates to X-ray diffraction and scattering mainly used for protein crystallography, small angle X-ray scattering, X-ray absorption, or X-ray fluorescence of material samples including biological samples.
Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold
Published in mAbs, 2023
Tiphanie Pruvost, Magali Mathieu, Steven Dubois, Bernard Maillère, Emmanuelle Vigne, Hervé Nozach
The complex between the first luminal domain of LAMP-1 (LAMP-1 29–195 produced in E. coli) and Fab B was concentrated to 12 mg/ml in 10 mM phosphate buffer saline pH 7. Crystallization was done by vapor diffusion using the sitting drop method. Crystals were obtained in 20% (w/v) polyethylene glycol 3350, 200 mM NaF. And, 25% (v/v) ethylene glycol was included as cryoprotectant prior to freezing. Datasets were collected at beamline ID29 from the synchrotron ESRF (European Synchrotron Radiation Facility) on a Pilatus 6 M at wavelength 0.976251 Å. The crystals belong to the space group C2 and diffracted to 2.37 Å. Data were processed using autoproc from GlobalPhasing53 which relies on the XDS54 and Aimless55 programs. Final processing statistics are listed in Supp. table 1.
Flying rats and microbeam paths crossing: the beauty of international interdisciplinary science
Published in International Journal of Radiation Biology, 2022
With Bräuer-Krisch having attracted several new research groups to the ESRF, by the time the long shutdown for the ESRF upgrade program began in December 2018, beamline ID17 had developed into something like the center of the microbeam research universe (Laissue 2021). A search in the Pubmed database shows more than eighty publications to the credit of Elke Bräuer-Krisch, more than 120 publications with her name on the authors list can be found in the Semantic Scholar database. Leading some of the development projects herself, like the introduction and characterization of new multislit collimators for MRT (Bräuer-Krisch et al. 2005, 2009; Pellicioli et al. 2021) and the exploration of new irradiation geometries (Bräuer-Krisch et al. 2005; Donzelli et al. 2019), she also inspired others to develop their own projects.
Elke Bräuer-Krisch: dedication, creativity and generosity: May 17, 1961–September 10, 2018
Published in International Journal of Radiation Biology, 2022
Elke acquired her basic formation as radiation protection engineer in Germany, at the Berufsakademie Karlsruhe (1980–1984). The following decade was devoted to an extensive international professional development, with residencies in: (A) Institut Laue Langevin, Grenoble, France (1984–1986). (B) National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory (Upton, NY) (1986–1987 and 1993–1994). (C) DESY (Deutsches Elektronen-Synchrotron, Hasylab) in Hamburg, Germany (1987–1988). (D) Australian Nuclear Science and Technology Organisation (ANSTO) in Sydney, Australia. (E) European Synchrotron Radiation Facility (ERSF) in Grenoble, France (1983–1990), where she moved to a position of safety engineer in 1990. In 1998, Elke joined the Biomedical Beamline at the ESRF. What happened in the years between?