NRON

NRON

NRON is a long non-coding RNA that regulates the nuclear trafficking of transcription factors, specifically the nuclear factor of activated T cells (NFAT), which affects the expression of genes activated by NFAT. NRON can bind to NFAT and prevent its nuclear accumulation, thereby inhibiting downstream reactions.From: Cancer Epigenetics [2019], lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression [2019]

Role of Epigenetics in Immunity and Immune Response to Vaccination

View Chapter

Purchase Book

Published in Mesut Karahan, Synthetic Peptide Vaccine Models, 2021

Necip Ozan Tiryakioğlu

For instance, in T cells the activity of the transcription factor, nuclear factor of activated T cells (NFAT), is inhibited by the lncRNA, noncoding repressor of NFAT (NRON). This results in the suppression of IL-2 production (Willingham et al. 2005). In another study, Wang et al. have shown that lnc-DC activates STAT3 while also blocking its dephosphorylation and contributes to differentiation of DCs (Wang et al. 2014).

lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression

View Article

Journal Information

Published in OncoImmunology, 2019

Mingyan Huang, Huamin Wang, Xiang Hu, Xuetao Cao

Continuing advances in transcriptomics revealed that long non-coding RNAs (lncRNAs) are one of the most important mediators in regulating differentiation and developmental processes and pathological responses. Abnormal expressions of lncRNAs like MALAT1, PCAT7, PVT1, and HOTAIR have been demonstrated to play important roles in tumorigenesis and tumor progression.18,19 LncRNAs can regulate gene expression at different levels, such as chromatin modification, transcription and post-transcriptional processing. Xist (X inactive specific transcript), the first identified lncRNA, recruits the polycomb complex to the X chromosome and then trimethylates lysine 27 residue of histone H3 to induce heterochromatin formation, finally rendering the silence of X chromosome.20 LncRNA NRON can bind to the transcription factor NFAT (nuclear factor of activated T cells) and impede nuclear accumulation of NFAT to inhibit downstream reactions.21

Explore chapters and articles related to this topic

Role of Epigenetics in Immunity and Immune Response to Vaccination

lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression