China
Africa
Explore chapters and articles related to this topic
Perinatal and Pediatric Outcome of Pregnancies Following PGT-M/SR/A
Published in Carlos Simón, Carmen Rubio, Handbook of Genetic Diagnostic Technologies in Reproductive Medicine, 2022
Malou Heijligers, Christine de Die-Smulders
Perinatal outcome of pregnancies following PGT has been the subject of much study [5,11–13,16–18]. A major concern regarding PGT was the increased risk of congenital abnormalities due to the embryo biopsy, especially because regular IVF with ICSI is already associated with an increased risk of birth defects [6]. Congenital abnormalities can be detected during pregnancy and after birth. Some of the prenatally detected abnormalities are not compatible with life and lead to intra-uterine fetal death or termination of pregnancy. Reports on congenital abnormalities differentiate between major and minor abnormalities, and between isolated and multiple abnormalities, the latter sometimes being part of a syndrome. Congenital abnormalities are defined as structural, functional, and genetic anomalies. Those that do not have serious medical, functional, or cosmetic consequences are considered minor.
A comprehensive review of hormonal and biological therapies for endometriosis: latest developments
Published in Expert Opinion on Biological Therapy, 2019
Fabio Barra, Giovanni Grandi, Matteo Tantari, Carolina Scala, Fabio Facchinetti, Simone Ferrero
Endometriosis can be asymptomatic; but most frequently it causes pain symptoms and/or infertility that severely impact women’ quality of life (QoL). The symptoms depends on the location of endometriotic lesions: intestinal symptoms can occur in case of bowel nodules [2] whereas urinary symptoms in case of the bladder [3] or ureteral endometriosis [4]. The precise prevalence of endometriosis is unknown because its definitive diagnosis requires surgery and histological evaluation. However, it has been estimated that this benign chronic disease affects at least 3.6% of the reproductive age women [5]; however, its prevalence could significantly increase considering women suffering pain symptoms and/or infertility [6]. The etiology of endometriosis is unclear: various factors, such as multiple abnormalities of the immune system, genetic factors, and environmental factors may influence women’ susceptibility to develop this chronic disease [7].