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The First-Episode of Psychosis and Suicide in Schizophrenia
Published in Ragy R. Girgis, Gary Brucato, Jeffrey A. Lieberman, Understanding and Caring for People with Schizophrenia, 2020
Ragy R. Girgis, Gary Brucato, Jeffrey A. Lieberman
Dr. Luca was A.’s gynecologist. A. did not like Dr. Luca. She felt that Dr. Luca had a terrible bedside manner and was superficial, arrogant, and fake. Dr. Luca would regularly try to persuade A. to take opioid medications for minor discomfort. A. continued to see Dr. Luca because he was a graduate of one of the top OB-GYN departments in the country. A. was not sorry that he was colonized.
Gene Therapy
Published in Howard Green, Therapy with Cultured Cells, 2019
This discovery was another contribution of the laboratory of M. De Luca and G. Pellegrini (Mavilio et al., 2006). They studied a severe genetically determined blistering disease of the skin — Junctional Epidermolysis Bullosa. The patient they studied was a double heterozygote containing a frame shift/single point mutation in the gene for Laminin 5-β3, which links basal epidermal cells to the basement membrane.
Ronald Aylmer Fisher (1890–1962)
Published in Krishna Dronamraju, A Century of Geneticists, 2018
Fisher never showed much interest in chromosomes or in genetic systems. Yet he was far from blind to novel developments. This was clear from his initiation (in Cambridge) of experimental work with bacteria in the early days of bacterial genetics—work that, in the hands of Luca L. Cavalli-Sforza, was fruitful despite the physical difficulties of the accommodation available for it, but which unfortunately came to an early end.
Placental levels of polycyclic aromatic hydrocarbons (PAHs) and their association with birth weight of infants
Published in Drug and Chemical Toxicology, 2022
Priyanka Agarwal, Madhu Anand, Paromita Chakraborty, Laxmi Singh, Jamson Masih, Ajay Taneja
The current study used the diagnostic ratio methods to determine the source of origin of PAHs in the exposed population (Table S3). According to De Luca et al. (2005), the ratio of LMW PAHs to HMW PAHs when <1 indicated the pyrogenic sources, while for the petrogenic sources, the above ratio is >1. In the current analysis, for the majority of samples, the calculated values are less than1, implying the pyrogenic source of origin of PAHs instead of the petrogenic one. This would also suggest that anthropogenic activities are the main sources of exposure as the majority of the studied population (65%), in addition to L.P.G., relies on the burning of biomass fuels as its cooking source. It was further supported by the calculated ratios of Fla/Fla + Pyr (>0.4), Fla/Pyr (>1), Anth/Anth + Phen (>0.1) (Lang and Cao 2010), Phen/Anth (<10) (Chen et al.2012) and IcdP/IcdP + BghiP (>0.2), BaA/BaA + Chr (>0.2) (Guo et al.2006), indicating that wood and coal combustion may be the primary sources responsible for exposure of the present population.
Tracing protein and proteome history with chronologies and networks: folding recapitulates evolution
Published in Expert Review of Proteomics, 2021
Gustavo Caetano-Anollés, M. Fayez Aziz, Fizza Mughal, Derek Caetano-Anollés
The comparative genomic analysis of structural domains in proteomes that began with Gerstein [100] informs about the lexicon, syntax and semantics of proteome vocabularies [101]. For example, Table 2 shows a decade-spanning series of analyses of SCOP FSF and FF distributions in the proteomes of superkingdoms and viruses [102–105]. The existence of ‘cores’ common to cellular life and viruses (Venn groups ABEV) and cellular life (ABE) (making up 20–26% of all domains) support both a last universal common ancestor (LUCA) and a last universal cellular ancestor (LUCellA) of life. A ‘periphery’ of domains specific or shared by groups suggest their late diversification, including vocabulary compression typical of microbial life [101]. Significant distribution biases, such as the supernumerary BE and BEV Venn groups, support a tripartite cellular world and an early origin of Archaea [106]. Groups that include viruses, while underrepresented, support wide structural exchange and very early viral origins [104,105]. Similar comparative genomic patterns can be extracted from Pfam domain data [107]. However, universal Pfam cores barely exceed 10%, showcasing the limitations of lower protein organization levels. Percent domain composition of each Venn group was quite constant despite significant increases in proteome and viral sampling (Table 2), suggesting comparative genomic patterns are robust. However, processes of reticulate evolution such as horizontal gene transfer complicate interpretations, prompting phylogenomic analyses.
CRISPR/Cas: from adaptive immune system in prokaryotes to therapeutic weapon against immune-related diseases
Published in International Reviews of Immunology, 2020
Juan Esteban Garcia-Robledo, María Claudia Barrera, Gabriel J. Tobón
All organisms are part of the three main branches of the tree of life, bacteria, archaea (prokaryotes), and eukaryotes, that split from a common Last Universal Common Ancestor (LUCA) [2, 15]. Multicellular eukaryotes comprising most of kingdom Animalia emerged approximately 600 million years ago during the metazoan age [16]. These metazoan organisms branched rapidly along different lineages, and about 500 million years ago multiple lineages emerged [16]. Even simple life forms such as prokaryotes and single-celled eukaryotes possess heritable innate immune mechanisms [17]. Alternatively, adaptive immune systems able to provide protection based on previous exposure to foreign invaders was thought to first appear with the rise of jawed vertebrates (a metazoan lineage) [16, 18]. The adaptive immune system is based on cellular and humoral components (T cells and B lymphocytes, respectively) expressing antigen-recognizing receptors. These receptors are formed by genetic recombination during cell fate determination and maturation, allowing for the creation of multiple cell clones expressing receptors specific for different epitopes of microorganisms [18, 19].