HSPB6

HSPB6

Football and healthy ageing

Published in Peter Krustrup, Daniel Parnell, Football as Medicine, 2019

Pasqualina Buono, Jesper L. Andersen, Andreina Alfieri, Annamaria Mancini, Stefania Orrù, Marie Hagman, Peter Krustrup

Very recently, it has been demonstrated that lifelong football training positively affects the expression of genes and proteins involved in auto-lysosomal and proteasome (RAD23A, HSPB6, RAB1B, TRAP1, SIRT2 and HSBPB1, in cell growth and differentiation (RPL1, RPL4, RPL36, MRLP37) and in autophagy pathways (Bcl-2, HSP70, HSP90, PSMD13 and ATG5-ATG12 protein complex) in skeletal muscle of football-trained veterans compared to age-matched untrained elderly subjects. These results suggest that lifelong football training promotes skeletal muscle longevity (Mancini et al. 2019).

Hyperosmolar Potassium Inhibits Corneal Myofibroblast Transformation and Prevent Corneal Scar

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Journal Information

Published in Current Eye Research, 2023

Kai Liao, Zekai Cui, Zhijie Wang, Yu Peng, Shibo Tang, Jiansu Chen

To further study the molecular mechanism underlying the effects of potassium, RNA-seq analysis was performed. Principal component analysis (PCA) results revealed significant differences between the KCl and control groups (Figure 4(A)). Pearson correlation analysis results demonstrated good repeatability of KCl treatment (Figure 4(B)). The differential gene expression results were visualized using a volcano plot. The upregulated genes in KCl group included FGF1, MAMDC2, DKK1, CRYAB, and SLC5A3, downregulated gene included NDNF, HSPB6, GAP43, PTGES, and TXNIP (Figure 4(C)). The screening identified 721 upregulated DEGs and 795 downregulated DEGs between the KCl and control groups. A heatmap was generated to display differential gene expression in the two groups (Figure 4(D)).

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Football and healthy ageing

Hyperosmolar Potassium Inhibits Corneal Myofibroblast Transformation and Prevent Corneal Scar