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HLA-DR and -DQ Serotyping
Published in M. Kam, Jeffrey L. Bidwell, Handbook of HLA TYPING TECHNIQUES, 2020
HLA-DR17 and DR18 (DR3). HLA-DR17 and DR18 are defined as splits of DR3 in the same way as the splits of DR2 (see above).8 HLA-DR17 is defined by positivity with monospecific sera with which DR18 is negative. No sera have yet been described that are DR17 negative, DR18 positive.
Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis
Published in Expert Review of Respiratory Medicine, 2020
MC Schimmelpennink, M Quanjel, ADM Vorselaars, I Wiertz, M Veltkamp, CHM Van Moorsel, JC Grutters
Löfgren’s syndrome is a clinical phenotype of sarcoidosis that is associated with a favorable prognosis. The typical clinical presentation of LS with an acute onset, fever, erythema nodosum, and arthritis suggests higher inflammatory activity than in patients with a more insidious onset of disease. On the basis of this hypothesis, one should expect even higher levels of sIL-2R in patients with LS in comparison to non-LS patients. In the study of Ziegenhagen et al. [35], no difference in sIL-2R between patients with LS in comparison to non-LS stable sarcoidosis patients was found, but patients with progressive non-LS sarcoidosis showed markedly higher levels of sIL-2R than patients with Löfgren’s syndrome. Planck and colleagues [36] found no difference in sIL-2R when comparing HLA DR 17 positive patients – which is associated with LS- to HLA DR17 negative patients; these results are in line with the findings in our cohort.
Lichen sclerosus of the vulva
Published in Climacteric, 2021
Studies that support genetic susceptibility in the pathogenesis of the condition indicate a significant association of LSV with genes regulating human leukocyte antigen (HLA) class II antigens, which are involved in humoral immunity. Women with LSV have an increased prevalence of HLA-DQ7, HLA-DQ8, HLA-DQ9 and HLA-DR12 compared with controls, with 50% of adult females expressing HLA-DQ7. In contrast, HLA-DR17 shows a negative association with LSV, inferring protective qualities. These specific HLA antigens and their associated haplotypes may play a role in susceptibility and protection from lichen sclerosus [11,12].