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Pharmaceuticals and Nutraceuticals from Fish and Their Activities
Published in Ramasamy Santhanam, Santhanam Ramesh, Subramanian Nivedhitha, Subbiah Balasundari, Pharmaceuticals and Nutraceuticals from Fish and Fish Wastes, 2022
Ramasamy Santhanam, Santhanam Ramesh, Subramanian Nivedhitha, Subbiah Balasundari
Antimicrobial activity: The purified fraction of protein derived from this species showed potent antimicrobial activity on Micrococcus luteus and weakest activity against Escherichia coli with MIC values of 4 and 12 µM, respectively. The protein also showed activity against the fungus species Candida tropicalis (Conceiçâo et al., 2012).
Factors Controlling the Microflora of the Skin
Published in Michael J. Hill, Philip D. Marsh, Human Microbial Ecology, 2020
Lysozyme is found at the skin surface,92,93 and this has been suggested as a control mechanism for the skin microflora. However, no specific studies seem to have been made to correlate lysozyme concentrations and skin microflora. Micrococcus luteus, which is extremely sensitive to lysozyme, is readily found on human skin, especially in children and women. The potential role of lysozyme in controlling certain staphylococci-bearing plasmids is discussed in the section on ecological genetics.
Antibacterial Activity of Seaweeds and their Extracts
Published in Leonel Pereira, Therapeutic and Nutritional Uses of Algae, 2018
Shanmughapriya et al. (2008) showed that extracts from Gracilaria corticata were found to be effective against Pseudomonas aeruginosa and Escherichia coli. It was also effective against Micrococcus luteus, Staphylococcus epidermidis, and Enterococcus faecalis.
Identification of a growth factor required for culturing specific fastidious oral bacteria
Published in Journal of Oral Microbiology, 2023
Pallavi Murugkar, Eric Dimise, Eric Stewart, Stéphane N. Viala, Jon Clardy, Floyd E. Dewhirst, Kim Lewis
Quinones MK4, Q1, Q2, Q4, Q9 and Q10 were obtained from Sigma, Q8 and MK8 were extracted and purified from E. coli and MK4, MK5, MK6, MK7 and MK8 were purified from Micrococcus luteus. Cells of E. coli or M. luteus were resuspended in 50 mL 3:2:1 ethanol, H2O, 25% sodium hydroxide. The cell suspension was then refluxed under inert atmosphere (argon) for 20 min at 100°C. The vessel was immediately cooled in an ice bath. The contents were then poured into a separating funnel and extracted three times with heptanes (~200 mL portions). The organic layers were collected, rinsed with brine and dried with anhydrous sodium sulfate. They were then completely dried in a rotary evaporator. The dried material was stored at −20°C under Argon gas until use. An Agilent Technologies 1200 Series High-Performance Liquid Chromatography system equipped with G1361A Prep Pumps and a G1315D diode array detector was used for purification of quinones, and Nuclear Magnetic Resonance (NMR) spectroscopy was used to elucidate the structure of quinones as described previously [5,23].
Antimicrobial treatment of Kocuria kristinae invasive infections: Systematic review
Published in Journal of Chemotherapy, 2019
Radica S. Živković Zarić, Ana V. Pejčić, Slobodan M. Janković, Marina J. Kostić, Miloš N. Milosavljević, Marko J. Milosavljević, Valentina D. Opančina
Resistance of K. kristinae isolates was the most frequent to penicillins, gentamycin and erythromycin. This could have been expected, since another representative of Micrococcaceae family – Micrococcus luteus, has significant plasmid-borne macrolide resistance [40], and high degree of utilization of penicillins and gentamycin was widespread for many decades. With such beneficial profile of K. kristinae susceptibility to antibiotics, it is not surprising that outcome of antibiotic treatment of invasive infections with K. kristinae was cure in majority of cases, with only one death reported. The patient who died had several severe comorbidities, such as diabetic foot, systemic hypertension and hemorrhagic stroke, and infection with such localization (endocarditis) has high mortality per se.
Dual effect biodegradable ciprofloxacin loaded implantable matrices for osteomyelitis: controlled release and osteointegration
Published in Drug Development and Industrial Pharmacy, 2018
Ahmed F. Hanafy, Hany S. M. Ali, Samar N. El Achy, EL-Sayed E. Habib
The inhibition zone (mm) and minimal inhibitory concentrations (MIC, µg/ml) of CPX samples kept from the release studies for coated CPX-IDs were evaluated. The unprocessed CPX was used as a control. Bone pathogens are known to cause osteomyelitis were used using the agar diffusion technique [21,22]. The tested pathogens were Staphylococcus aureus IFO 3060, Bacillus subtilis IFO 3007, Micrococcus luteus IFO 3232 (Gram positive bacteria), and Escherichia coli IFO 3301, Pseudomonas aeruginosa IFO 3448 (Gram negative bacteria). Briefly, the unprocessed CPX was dissolved in distilled water at a concentration of 64 µg/ml. The two-fold dilutions of the solution were prepared (64, 32, 16, 8, 4, 2, 1, 0.5, and 0.25 µg/ml). The microorganism suspensions at 106 CFU/ml (colony forming unit/ml) were inoculated onto agar plates. The antibiotic concentrations were inoculated to the corresponding wells, and this was followed by pre-diffusion at room temperature for 30 min and then by overnight incubation at 37 °C. The clear zone (inhibition zone) around each compound was measured in (mm). The MIC (µg/ml) values were determined as the lowest concentration that inhibited the growth of the microorganism.