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Wolbachia-Virus interactions and arbovirus control through population replacement in mosquitoes
Published in Pathogens and Global Health, 2023
Thomas H Ant, Maria Vittoria Mancini, Cameron J McNamara, Stephanie M Rainey, Steven P Sinkins
Asselin et al. 2019 [102] characterized two native Wolbachia infections in Drosophila pandora: wPanMK and wPanCI. Challenge of flies with cricket paralysis virus (CrPV), a (+)RNA virus from the Family Dicistroviridae, revealed that wPanMK was associated with reduced CrPV-induced mortality, while wPanCI was associated with increased mortality compared to Wolbachia-negative controls. Measurements of viral titers showed no significant differences in CrPV levels between the fly lines (although only one timepoint was used), suggesting that the Wolbachia infections did not have a direct impact on CrPV replication, but rather appeared to affect the ability of D. pandora to tolerate the infection.