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Chlamydial Lipopolysaccharide
Published in Helmut Brade, Steven M. Opal, Stefanie N. Vogel, David C. Morrison, Endotoxin in Health and Disease, 2020
Chlamydiae undergo a unique developmental cycle inside the infected host cell which is so characteristic and unique that they were taxonomically set apart from other bacteria into their own order Chlamydiales (38). Although the species share a DNA homology of only 10% as determined by DNA-DNA hybridization (40), their common origin is deduced from the homology of their 16S rRNA of more than 95% (41,42).
Chlamydia Pneumonitis
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
Chlamydia, obligate intracellular parasites, are classified in their own order Chlamydiales with one genus (Chlamydia) and two species (C. psittaci and C. trachomatis). The major differences between the two species are that C. psittaci are resistant to sulphonamides and do not stain with iodine.
Chlamydia trachomatis
Published in Peter M. Lydyard, Michael F. Cole, John Holton, William L. Irving, Nino Porakishvili, Pradhib Venkatesan, Katherine N. Ward, Case Studies in Infectious Disease, 2010
Peter M. Lydyard, Michael F. Cole, John Holton, William L. Irving, Nino Porakishvili, Pradhib Venkatesan, Katherine N. Ward
This patient was infected with Chlamydia trachomatis, which belongs to the Family Chlamydiaceae of the Order Chlamydiales. Until recently Chlamydiaceae was believed to consist of one genus Chlamydia, but now another genus, Chlamydophila, has been identified within this Family. Bacteria of this Family are obligate intracellular human and animal pathogens. The term ‘Chlamydia’ is derived from the word ‘chlamys,’ which means cloak (Khlamus) in Greek, an appropriate name reflecting the cloak-like chlamydial inclusion around the host cell nucleus (see below).
Quinazoline and quinazolinone as important medicinal scaffolds: a comparative patent review (2011–2016)
Published in Expert Opinion on Therapeutic Patents, 2018
Abdul Hameed, Mariya Al-Rashida, Maliha Uroos, Syed Abid Ali, Marium Ishtiaq, Khalid Mohammed Khan
The antibacterial potential of quinazolines and quinazolinones has been enormously explored. Chlamydiae belong to the chlamydiaceae family (order chlamydiales) that includes two genera: chlamydia and chlamydophila. Mammalian pathogenic bacteria from chlamydiales order include Chlamydia trachomatis, which is responsible for diseases such as ocular and lung infections, and sexually transmitted diseases (STD). Chlamydophila peuumonia is responsible for causing pneumonia while chlamydia is also responsible for reactive arthritis infections of urogenital tract causing prostatitis, pelvic inflammatory disease, and increased risk of ectopic pregnancy or infertility in women [9]. Although antibiotic resistance is considered rare for Chlamydia trachomatis, it is widespread in several sexually transmitted bacteria, e.g. Neisseria gonorrhoeae or Mycoplasm genitallium. The rapid spread of azithromycin resistance among these bacteria has been attributed to the frequent treatment of patients with chlamydial infection with this antibiotic. Hence, discovery of new compounds to overcome bacterial resistance is of utmost importance. Structures of some of the quinozalinone-based compounds active as anti-chlamydial compounds bearing thiol and thiazole substituents are shown in Figure 4, Scheme 1 [10].