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Order Nidovirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
As reviewed by de Groot et al. (2012), the structural proteins of arteriviruses are apparently unrelated to those of the other members of the order Nidovirales. In porcine reproductive and respiratory syndrome virus (PRRSV), a single member the Betaarterivirus suid 1 species from the subgenus Eurpobartevirus, genus Betaarterivirus, subfamily Variarterivirinae, and equine arteritis virus (EAV), a single member of the Alphaarterivirus equid species from the genus Alphaarterivirus, subfamily Equarterivirinae, six envelope proteins have been identified, each essential for virion infectivity, while a single protein species, N, forms the nucleocapsid. As shown in Figure 26.1, the nonglycosylated membrane protein M structurally resembles the M protein of coronaviruses. It forms a disulfide-linked heterodimer with the major glycoprotein GP5, which is also a putative triple-spanning membrane protein. The viral glycoproteins GP2, GP3, and GP4 are minor virion components and form heterotrimers. The envelope protein E is small, hydrophobic, and nonglycosylated and believed to function as an ion-channel protein.
Research progress in the development of porcine reproductive and respiratory syndrome virus as a viral vector for foreign gene expression and delivery
Published in Expert Review of Vaccines, 2020
Guo Dai, Mei Huang, To Sing Fung, Ding Xiang Liu
PRRSV belongs to the genus Porarterivirus, together with the other four genera, Equarterivirus, Simarterivirus, Diparterivirus, Nesarterivirus, placing within the family Arteriviridae of the order Nidovirales [4]. This family includes other members, such as lactate dehydrogenase-elevating virus of mice (LDV), simian hemorrhagic fever virus (SHFV), equine arterivirus (EAV) and the recently described wobbly possum disease virus (WPDV) [1,5,6]. According to the latest classification system, the traditional two genotypes of PRRSV, European (Type 1) and North American (Type 2), can be reclassified into two different species, betaarterivirus suid 1 species for PRRSV 1 and betaarterivirus suid 2 for PRRSV 2, sharing less than 70% sequence identity [7].