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Order Asfuvirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
According to the present ICTV (2020) situation, the extremely small Asfuvirales order currently includes a sole family Asfarviridae with the sole genus Asfivirus involving the only recognized African swine fever virus species, well known because of its ecological and economical danger. The order Asfuvirales, together with the well-known Chitovirales order including the famous Poxviridae family, which is touched on briefly in Chapter 5, forms the class Pokkesviricetes. The latter, together with the class Megaviricetes, forms the Nucleocytoviricota phylum. The latter, together with the Preplasmiviricota phylum, forms the Bamfordvirae kingdom, while the latter, together with the kingdom Helvetiavirae, belongs in turn to the great realm Varidnaviria.
Torovirus
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
Ziton Abdulrida Ighewish Al-Khafaji, Ghanim Aboud Al-Mola
Viroplasms are electronic dense cytoplasmic inclusions where viral replication and assembly take place. They are produced by nucleocytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae, and Iridoviridae, dsRNA viruses like Reoviridae and ssRNA(-) viruses like Filoviridae [40].
The roles of epidermal growth factor receptor in viral infections
Published in Growth Factors, 2022
Africa swine fever virus (ASFV) is the only member of family Asfarviridae. It is a large, icosahedron, double-stranded DNA virus that infects domestic and wild swine. ASFV targets monocyte/macrophage lineage and causes highly fatal haemorrhagic fevers in swine (Gaudreault et al. 2020). A study by Sánchez et al. (2012) has reported the role of EGFR in ASFV infection. Activation of EGFR and its downstream PI3K/AKT signalling pathway is essential for ASFV entry into the cells via macropinocytosis mechanism. Pre-treatment of irreversible EGFR inhibitor, 324674 inhibited uptakes of ASFV into Vero cells in a dose-dependent manner (Figure 2(a)) (Sánchez et al. 2012)
Inhibition of African swine fever virus protease by myricetin and myricitrin
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim
ASF is caused by the ASF virus (ASFV), a large, enveloped virus containing a 170–193 kbp double-stranded DNA encoding more than 150 genes. It is the only member of Asfarviridae family6. ASFV employs a polyprotein processing at Gly-Gly-Xaa sites to produce several core components of viral particles. The virus gene S273R encodes 31 kDa protein containing a “core areas” with the characteristics of SUMO-1 specific protease and adenovirus protease. The S273R product (ASFV protease) is known as the protease involved in the processing of the ASFV polyproteins pp220 and pp62. Therefore, ASFV protease is a good drug target for anti-ASFV infection7.