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Order Zurhausenvirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
The human papillomavirus type 16 (HPV16) belonging to the Alphapapillomavirus 9 species is a reference strain of the Alphapapillomavirus genus. The members of this genus preferentially infect the oral or anogenital mucosa in humans and primates, while specific members of certain species (e.g. Alphapapillomavirus 7 and Alphapapillomavirus 9) are considered as oncogenic in view of their regular presence in malignant tissue. All members of this genus code for a hydrophobic E5 protein, located at the 3′-end of the early region (Van Doorslaer et al. 2018).
Biology
Published in William Bonnez, Guide to Genital HPV Diseases and Prevention, 2019
Robert C. Rose, Mark H. Stoler
The third group is made of the genital HPVs, also called mucosal HPVs, because they infect the mucous membranes of not only the anogenital tract, but also of the upper aerodigestive tract. The genital papillomaviruses belong to the Alphapapillomavirus genus. Their phylogeny is shown in Figure 1.2. Within the genus, different species are recognized, each with a representative genotype. For the purpose of this book, it is important to recognize that HPV-6 is the representative type of species 10, to which HPV-11 also belongs; HPV-16 is the representative of species 9, and HPV-18 of species 7. What accounts for tissue tropism is not well understood.
Prospective Therapies of Genital Human Papillomavirus Infections
Published in Satya Prakash Gupta, Cancer-Causing Viruses and Their Inhibitors, 2014
Ricardo Ney Oliveira Cobucci, Janaina Cristiana de Oliveira Crispim, Ana Katherine da Silveira Gonçalves
HPVs are grouped according to the type of epithelia they infect. At present, there are about 40 HPVs infecting the mucosal sites of the body, including the anogenital tract of both genders. All HPV genotypes infecting the genital tract belong to the alphapapillomavirus genus, which includes 15 species and 58 HPV genotypes. All genotypes are also classified according to their clinical behavior (i.e., association with malignancy) into high-risk (HR) types, low-risk (LR) types and probable HR types.
Human papillomavirus in foetal and maternal tissues from miscarriage cases
Published in Journal of Obstetrics and Gynaecology, 2018
Luciana Bueno de Freitas, Christiane Curi Pereira, Paulo Roberto Merçon-de-Vargas, Liliana Cruz Spano
HPV belongs to the Papillomaviridae family, an epitheliotropic DNA virus that has approximately 200 different types, almost 40 of which are associated with anogenital infections. The mucosal types belong to the Alphapapillomavirus genus and were classified as high-risk (HR-HPV) and low-risk (LR-HPV) types, according to their cervical carcinogen potential (Bernard et al. 2010; PaVE 2017).