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Outcome of Minimally Invasive Management of Salivary Calculi in 4,691 Patients
Published in Niall MH McLeod, Peter A Brennan, 50 Landmark Papers every Oral & Maxillofacial Surgeon Should Know, 2020
Katherine S George, Rafal Niziol
All patients with symptomatic disease, or at least one episode of purulent sialoadenitis, with no recovery after 3 months of conservative therapy and not amenable to simple intraoral release were included in the study.
The salivary glands
Published in Neeraj Sethi, R. James A. England, Neil de Zoysa, Head, Neck and Thyroid Surgery, 2020
Sialolithiasis is the main cause of obstructive sialadenitis. The submandibular gland is involved in 80%–90% of cases, followed by the parotid gland (95%–10%) and sublingual glands (<1%). Calculi vary in size and can be single or multiple. The formation of stones is associated with chronic sialadenitis [8].
Non-Neoplastic Salivary Gland Diseases
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Stephen R. Porter, Stefano Fedele, Valeria Mercadante
The benefits of sialography for the diagnosis of acute suppurative sialadenitis remain unclear. Some authorities suggest that such investigation is contraindicated (probably when there is notable disease), while others suggest that it may resolve any causative ductal stricture. Sialography may reveal areas of ductal stricture and sialectasis, the latter are most likely with recurrent disease. Scintiscanning is generally unhelpful but may sometimes reveal the underlying cause (e.g. poor salivary gland function). Ultrasound scanning is useful as it may identify sialoliths, ductal anomalies, fluid collections and parenchymal disease of probable Sjögren’s syndrome or HIV disease. Additional cross-sectional imaging may be essential if abscess formation is suspected.
Prevotella species as oral residents and infectious agents with potential impact on systemic conditions
Published in Journal of Oral Microbiology, 2022
Eija Könönen, Dareen Fteita, Ulvi K. Gursoy, Mervi Gursoy
Sjögren’s syndrome (SS), an autoimmune disease, typically affects the salivary and lacrimal glands. In a Norwegian study, the composition of the salivary microbiome was examined in 45 women divided into primary-SS (p-SS), dry mouth (non-SS), and healthy control groups [167]. The mean relative abundance of the genus Prevotella was around 30%, and P. histicola, P. melaninogenica, and P. salivae were among the core microbiomes in all three groups. However, dysbiotic shifts in the salivary microbiota, including significantly reduced abundance of P. pallens and detection of P. nanceiencis and P. intermedia, were observed only in women with disturbed saliva secretion [167]. In a Korean study, comparing 25 women with p-SS and 25 controls with or without dry mouth, P. melaninogenica was highly associated (OR 22.4) with Sjögren’s syndrome [168]. Labial salivary gland biopsies with focal sialoadenitis revealed a high presence of bacteria, including P. melaninogenica, within the ductal cells and in the area of infiltration. In order to understand the bacterial involvement in the etiopathogenesis of Sjögren’s syndrome and in the functional and phenotypic changes in salivary glands, the authors used a human submandibular gland tumor cell model [168]. According to the results, P. melaninogenica increased and P. histicola decreased interferon (IFN)-λ production. Moreover, P. melaninogenica induced the deregulation of submandibular gland cells.
Ectopic tonsil in the floor of the mouth: A case report
Published in Acta Oto-Laryngologica Case Reports, 2021
Clinical examination revealed about 1 cm large non-fluctuating, non-tender evenly soft submucosal mass on the floor of the mouth, just under and to the left side of the tongue, near the left sublingual salivary gland as seen in Figure 1. The rest of the floor of the mouth was palpated without remark. No other enlarged mass was palpable in the head and neck region. Preliminary diagnosis set as sialoadenitis of the left sublingual salivary gland or mucocele. It was decided to stick the lump with a fine needle. A small amount of yellowish secret was aspirated and sent only for bacteriological examination. Unfortunately, the aspirated secret was not examined by the pathologist and no cytological analysis was done. The patient was told that in case the mass begins to fill up, surgical removal under local anesthesia would be suggested. The culture report revealed sparse growth of the Actinomyces hongkongensis bacteria which may be part of the normal flora but can sometimes cause abscess and in rare cases even actinonomycosis. Resistance and sensitivity patterns revealed that the bacteria were sensitive to both benzyl penicillin and clindamycin antibiotics. Even though the patient had no clinical signs of infection, but since there was a certain risk for the bacteria to cause abscess, she was put on treatment with antibiotic, clindamycin for two weeks according to the recommendation of the infection’s clinic.
Salivette, a relevant saliva sampling device for SARS-CoV-2 detection
Published in Journal of Oral Microbiology, 2021
Monique Melo Costa, Nicolas Benoit, Jerome Dormoi, Remy Amalvict, Nicolas Gomez, Hervé Tissot-Dupont, Matthieu Million, Bruno Pradines, Samuel Granjeaud, Lionel Almeras
The risk to fail in saliva sampling seems less frequent than for NPSs. In a recent study assessing the efficiency of Salivette® for screening SARS-CoV-2 hospitalized cases, 12.2% (6/49) of patients were excluded for failing saliva volume [48]. Sialadenitis, an acute inflammation of salivary glands reported in COVID-19 patients, could lead to a decrease of salivary flow compromising saliva collection [59]. We observed an insufficient volume of saliva in 11.2% of the samples (n = 34). The large majority of these individuals (29/34; 85.3%) were tested SARS-CoV-2 negative in saliva, suggesting that, here, lower salivation could not be attributed to viral infection. Concerning the human cellular RNA control, adding water did not impair the detection of the HRNP. Although significant differences of HRNP Ct values were noticed between diluted and not diluted saliva samples, the SARS-CoV-2 detection in five saliva specimens underlined that viral detection does not seem altered by diluting saliva. The water addition at the top of the cotton roll allowed to recover most of the saliva samples (n = 33/34, 97.1%), for which HRNP was detected. Finally, water addition did not compromised RNA detection and the RNA integrity control allows to reduce false negative detection. To reduce the proportion of samples for which the saliva volume retrieved were insufficient, a better explanation of its use with a short video describing the proper use of Salivette would be helpful.