China
Africa
Explore chapters and articles related to this topic
Other Reactions from Gloves
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
T. Bullock, A. Sood, J.S. Taylor
Diagnosis of chemical leukoderma is more easily made when a number of cases are clustered in a factory, and there is a history of worker exposure to a known depigmenting agent; when pigment loss follows contact dermatitis; or when the person affected is an adult without childhood or family history of vitiligo.23 Patch tests with putative depigmenting agents may result in leukoderma at the sites of positive or negative tests for up to six weeks or more after application. Satellite depigmentation may occur, and patch testing should be done cautiously (we prefer to patch test on the buttocks) with unknown chemicals. Application of the putative chemicals to black guinea pigs23 and identification of unknown depigmenting agents by HPLC18 are alternative test methods.
Piebaldism
Published in Electra Nicolaidou, Clio Dessinioti, Andreas D. Katsambas, Hypopigmentation, 2019
Jovan Lalošević, Miloš Nikolić
The most prominent characteristic is the white forelock (poliosis) (Figures 15.1 and 15.2) present in 80%–90% of patients with piebaldism. The white forelock typically appears in a triangular shape and the underlying skin of the scalp also is amelanotic (Figure 15.1). The eyebrows and eyelashes may also be involved9 (Figure 15.1). Together with poliosis, patients may have leukoderma, classically distributed on the central forehead and anterior trunk (Figure 15.3), with extension on the flanks, anterior aspects of the medial arm, and leg regions (Figure 15.4). Sparing of the dorsal midline (Figure 15.3), hands, feet, and periorificial area is characteristic. Leukoderma is commonly stable throughout life, although additional hyperpigmented macules (Figures 15.3 and 15.4) may develop at or within the margins of the white patches.10 Also, there are few reports on spontaneous repigmentation in infants, and even more sparse reports on repigmentation in older children and adults.11,12
Neurocutaneous Syndromes With Interstitial Lung Disease
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
The presence of one or more tufts of white hair in an infant with seizures is suggestive of a diagnosis of tuberous sclerosis.6 There seems to be an increased incidence of tuberous sclerosis in partial albinism.7 A peculiar form of speckled leukoderma is the so-called white freckles. Characterized as multiple 1 to 3 mm hypopigmented lesions arranged in a confettilike pattern on the pretibial area in some patients with tuberous sclerosis, it can also serve as a helpful marker of the disease. These lesions may very occasionally be found in normal individuals.3
TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease
Published in Ocular Immunology and Inflammation, 2020
Xia Ding, Yuan Cao, Yue Xing, Shengfang Ge, Ming Lin, Jin Li
To investigate the clinical features of AOXGD, clinical data from 22 patients diagnosed with AOXGD were collected and reviewed. The basic information collected, which included the patients’ age, gender, disease duration, margin reflex distance 1 (MRD1), and orbital involvement, is shown in Table 1. All the patients (44 eyes) exhibited bilateral involvement with the typical symptoms of nodularity, yellow discoloration and eyelid swelling (Figure 1). In addition, some patients showed orbital involvement and other systemic diseases. Orbital involvement was detected in 13 cases (59%) through CT or MRI, and this involvement was characterized by lacrimal gland enlargement in eight patients, lacrimal gland prolapse in four patients, and extraocular muscle enlargement in four patients. Five patients had a history of adult-onset asthma, one patient had a history of leukoderma, and the other 16 patients had no history of systemic diseases. Pathological examinations were performed, and the results showed a large number of mononuclear foam cells, plasma cells, lymphocytes and Touton giant cells accompanied by fibrosis or necrosis (Figure 2). All the patients were subjected to follow-up examinations 1 week, 1 month, 3 months, 6 months, and 1 year after treatment and experienced achieved satisfactory outcomes with marked correction of ptosis, improved eyelid fullness and a satisfactory contour after treatment. At the follow-up time point of 6 months, no local recurrence was observed in any of the patients.
Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo
Published in Journal of Dermatological Treatment, 2019
Sanne E. Uitentuis, Vidhya S. Narayan, Bas S. Wind, Marcel W. Bekkenk, Menno A. de Rie, Albert Wolkerstorfer
Non-segmental vitiligo (NSV) is an acquired chronic pigment disorder of the skin characterized by the development of patchy leukoderma, with a significant negative effect on the quality of life (1–3). NSV is the most common depigmenting disorder affecting approximately 1% of the world’s population, regardless of gender, ethnicity or skin type (4). Current treatments include topical agents, phototherapy and surgical techniques which aim to improve melanocyte proliferation and stimulate repigmentation (5). Topical therapy with corticosteroids or calcineurin inhibitors are suggested as first-line treatment (6). The use of narrow band ultraviolet B (NB-UVB) phototherapy was first reported in 1997 by Westerhof et al. (7) and is now considered to be a growing modality for the treatment of generalized NSV (5). NB-UVB is superior to psoralen and UVA (PUVA, another commonly used phototherapy regimen in vitiligo) due to its increased efficacy and decreased adverse effects (8,9).
Outcomes of autologous non-cultured melanocyte keratinocyte transplantation in vitiligo and nevus depigmentosus
Published in Journal of Dermatological Treatment, 2022
Thanyanan Sritanyarat, Chanisada Wongpraparut, Natchaya Jansuwan, Punyanut Yothachai, Nuttaporn Nuntawisuttiwong, Narumol Silpa-archa
Nevus depigmentosus is an uncommon congenital leukoderma disorder that appears as a localized, non-progressive, well-circumscribed depigmented patch with irregular border – predominantly on the trunk, extremities, and face (6). The etiopathogenesis remains unclear. However, the etiopathogenesis was proposed to be a defect in the transportation of melanosomes to keratinocytes (6,7). To date – several treatments, including narrowband ultraviolet B (NBUVB), psoralen plus UVA (PUVA), 308-nm excimer laser, and surgical grafting method, have shown varying rates of success (8–10).