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Kaposi's Sarcoma
Published in Debjani Sahni, Adam Lerner, Bilal Fawaz, Advanced Skin Cancer, 2022
Significant clinical and histologic overlap exists between all variants. The disease often begins with pink-violaceous-brown macules, patches, and plaques, which may progress to form larger nodules and tumors.2,3 Mucosal involvement is frequently present, particularly in the oral cavity.2 Histologic findings are common to all variants but vary according to stage.2 Patch/plaque-stage KS presents with a superficial/deep dermal proliferation of angulated vessels and spindled endothelial cells lacking significant atypia or mitoses. A sparse lymphoplasmacytic infiltrate is typically present.2 In nodular KS, spindled endothelial cells replace dermal collagen and form slit-like vascular spaces with erythrocyte extravasation.2 Immunohistochemical expression of latency-associated nuclear antigen (LANA-1) of HHV-8 confirms the diagnosis, as it is highly specific and sensitive for KS.3
Epilogue
Published in Lucy Jane Miller, Developing Norm-Referenced Standardized Tests, 2020
We had been funded to field test a Development Edition and a Standardization Edition of the test nationwide. It was a one-year grant. Thus we had three months to construct the Development Edition and kits, three months to field test it, three months to analyze the data and construct the Standardization Edition and kits, and three months to administer the Standardization Edition. Many, many lessons were learned “the hard way” during this phase. There were numerous excellent consultants who assisted with item content and training the examiners such as Lana Warren (in the area of neurodevelopment). There were also several extreme disappointments such as a tester who lied about having tested her sample, and did not admit that she had no children tested until two weeks before the end of the project. (During those final two weeks six examiners were trained and with the help of Pamela Lemerand, Charlotte Royeen and others in that geographic location, 130 children were randomly selected and tested!)
Difficult Conversations
Published in Ellen J Belzer, Skills Training in Communication and Related Topics Part 1, 2018
You are Barry White, MD, director of a large family medicine residency program. Because your associate director decided to accept a position in another State, you must select her successor. After careful thought, you’ve decided to hire Dr. Lana Lane for this position. Even though Dr. Lane has never worked at your hospital before, you worked with her at another medical center several years ago and remain impressed with her excellent administrative skills and professional judgment.
The Matrixial Gaze: Transgender in Boys Don’t Cry
Published in Studies in Gender and Sexuality, 2022
It is helpful to consider, as Ettinger does in her writing on the matrixial gaze, that “failure is the measure of what has been recognized” (as quoted by Butler, 2006, p. ix). In other words, the moment recognition takes effect, we miss something in the matrixial dimension, something of the OSD relevant to the subject-as-several. It seems to me that Lana knows this. She confirms that Brandon is a “guy” to save his life (even as she, ultimately, fails), but knows there is more at stake than gender confirmation in phallic and cisgender terms. As his lover, she is co-affected by and participates in his becoming. There is, in other words, a “participation-beyond-identification, participation-before-identification and even participation-beside-identification and beyond identity” (Ettinger, 2012, p. 196) in the matrixial. What counts as recognition in the phallic stratum corresponds to what is disappeared in the matrixial substratum.
Human oncogenic viruses: an overview of protein biomarkers in viral cancers and their potential use in clinics
Published in Expert Review of Anticancer Therapy, 2022
HHV8, also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), is an enveloped, large, double-stranded DNA virus. Like EBV, HHV8 belongs to the herpesvirus family. The HHV8 genome encodes approximately 100 genes [54], of which LANA plays an important role in the development of HHV8-associated cancers [55]. The incidence of HHV8 infection is inconsistent and the highest HHV8 infection incidence is found in Sub-Saharan Africa, accounting for up to 90% of the adult population [56].
Engagement in community life: perspectives of youths with intellectual and developmental disabilities on families’ roles
Published in Disability and Rehabilitation, 2020
Denise DuBois, Rebecca Renwick, Mushfika Chowdhury, Shauna Eisen, Debra Cameron
The final sub-theme which the youths described as influencing their community involvement was support for making choices and decisions. At times the youths were explicit about what choices they made and what choices their parents made for them. Some of the previous quotes from Olaf and Sergio about setting up outings with friends and Hannah wanting to choose music played in the car demonstrated these processes. Lana provided yet another example: