China
Africa
Explore chapters and articles related to this topic
Dermatitides
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Allison Perz, Tara Jennings, Robert Duffy, Warren Heymann
Laboratory studies: The diagnosis is usually obvious; otherwise, careful medical history should be taken to rule out other causes of pruritic dry skin, such as hypothyroidism or malignancy, which is referred to as acquired ichthyosis. A biopsy will demonstrate nonspecific spongiosis and acanthosis, sometimes with a superficial lymphocytic infiltrate and a diminished granular layer.
Retinoids in Keratinization Disorders
Published in Ayse Serap Karadag, Berna Aksoy, Lawrence Charles Parish, Retinoids in Dermatology, 2019
Acquired ichthyosis is an uncommon condition. Underlying diseases such as Hodgkin lymphoma, other lymphomas, sarcoidosis, leprosy, malabsorption, hypothyroidism, and a poor diet should be investigated if ichthyosis appears suddenly in adulthood period.
Systemic disease and the skin
Published in Ronald Marks, Richard Motley, Common Skin Diseases, 2019
Other causes of acquired ichthyosis include acquired immune deficiency syndrome (AIDS), sarcoidosis and leprosy, but if these can be excluded, a neoplastic cause is the most likely explanation (Fig. 21.7).
Seborrheic dermatitis with massive facial hyperkeratosis resembling acquired ichthyosis
Published in Baylor University Medical Center Proceedings, 2020
Brett A. Austin, Alan Vu, William D. Boothe, Cloyce L. Stetson
Although massive hyperkeratosis is unusual for SD, the diagnosis was supported by the symmetric distribution of hyperkeratotic scale on our patient’s face, the presence of budding yeast on the biopsy, and the near complete resolution with oral fluconazole and topical ketoconazole shampoo treatment. In this patient’s case, ketoconazole shampoo was preferable to cream as it is washed off after 5 min, avoiding messy buildup. Clinically there was minimal erythema and no pruritus, as seen in pityriasis versicolor, another Malassezia dermatosis, though our patient lacked truncal involvement. Differential diagnoses of acquired ichthyosis and acrokeratosis paraneoplastica of Bazex were also considered but were not supported by the lack of additional exam findings; in particular, the patient’s acral skin and legs were unremarkable. This presentation highlights the hyperproliferative processes underlying SD’s pathophysiology and may provide insight into Malassezia’s role in the development of SD.
Paraneoplastic eczematous eruption associated with Hodgkin’s lymphoma
Published in Baylor University Medical Center Proceedings, 2019
Usman Asad, Brett Austin, Ashley Sturgeon, Cloyce Stetson
Skin lesions associated with HD occur in 17% to 53% of patients.7–9 Specific dermal involvement secondary to direct extension via retrograde lymphatic spread from cancerous lymph nodes is rare and is associated with advanced (stage IV) nodal or visceral disease.10 Nonspecific skin lesions associated with HD often represent a paraneoplastic syndrome and account for the majority of reported cases, occurring in 10% to 50% of patients with HD.5,8–11 Diffuse hyperpigmentation, prurigo nodularis, acquired ichthyosis, erythema nodosum, mycosis fungoides, herpes zoster, and acquired perforating collagenosis have all been described as nonspecific manifestations of HD.10,12–15 Although eczematous dermatitis and chronic idiopathic erythroderma are known to precede the diagnosis of cutaneous T-cell lymphoma, it is not commonly associated with the diagnosis of noncutaneous lymphoma such as classical HD. Two published cases describe adult-onset recalcitrant eczema that preceded HD diagnosis and one case of eczema exacerbation that preceded non-Hodgkin’s lymphoma.16,17 In a recent retrospective study of a large group of patients with HD, pruritus and eczema were the most common dermatological findings. The authors suggest that patients with eczema, mycosis fungoides, and HD have a similar propensity to T-cell dysregulation and increased Th2 cytokine profiles conducive to atopy, which accounts for the similar cutaneous presentations among the three diseases.10 Treatment of HD led to the resolution of the eczematous eruptions in both our patient and the patients described in the literature.